A strain-promoted alkyne-azide cycloaddition (SPAAC) reaction of a novel EpCAM aptamer-fluorescent conjugate for imaging of cancer cells Subramanian, N, Sreemanthula, JB, Balaji, B, Kanwar, JR, Biswas, J and Krishnakumar, S 2014, A strain-promoted alkyne-azide cycloaddition (SPAAC) reaction of a novel EpCAM aptamer-fluorescent conjugate for imaging of cancer cells, Chemical Communications, vol. 50, no. 80, pp. 11810-11813, doi: 10.1039/c4cc02996h. Attached Files Name Description MIMEType Size Downloads Title A strain-promoted alkyne-azide cycloaddition (SPAAC) reaction of a novel EpCAM aptamer-fluorescent conjugate for imaging of cancer cells Author(s) Subramanian, N Sreemanthula, JB Balaji, B Kanwar, JR orcid.org/0000-0003-3728-9568 Biswas, J Krishnakumar, S Journal name Chemical Communications Volume number 50 Issue number 80 Start page 11810 End page 11813 Total pages 4 Publisher Royal Society of Chemistry Place of publication Cambridge, England Publication date 2014-10-14 ISSN 1364-548X Keyword(s) Science & Technology Physical Sciences Chemistry, Multidisciplinary Chemistry TARGETED DRUG-DELIVERY ADHESION MOLECULE APTAMER CLICK CONJUGATION SELECTION THERAPY Summary For the first time, a novel EpCAM aptamer (SYL3C)-DIBO-AF594 fluorescent conjugate was synthesised by bioorthogonal chemistry utilizing a strain promoted alkyne-azide cycloaddition (copper free click) reaction (SPAAC). The ligation efficiency of SPAAC was improved by freeze-thaw cycles. The obtained conjugate showed target specific binding and aided in the imaging of various EpCAM positive cancer cell lines like MCF7, MDAMB453, Weri-RB1 and PC3. Language eng DOI 10.1039/c4cc02996h Field of Research 111201 Cancer Cell Biology Socio Economic Objective 920102 Cancer and Related Disorders HERDC Research category C1 Refereed article in a scholarly journal ERA Research output type C Journal article Copyright notice ©2014, Royal Society of Chemistry Persistent URL http://hdl.handle.net/10536/DRO/DU:30067541 Document type: Journal Article Collection: School of Medicine Related Links Link Description Connect to published version Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Versions Version Filter Type Tue, 18 Nov 2014, 14:26:52 EST Mon, 08 Dec 2014, 13:09:07 EST Mon, 08 Dec 2014, 13:13:25 EST Mon, 08 Dec 2014, 13:20:17 EST Thu, 11 Dec 2014, 12:36:43 EST Thu, 11 Dec 2014, 12:37:33 EST Wed, 14 Oct 2015, 13:57:27 EST Mon, 12 Feb 2018, 10:02:30 EST Mon, 12 Feb 2018, 10:03:29 EST Filtered Full Citation counts:   Cited 9 times in TR Web of Science Cited 14 times in Scopus Search Google Scholar Access Statistics: 257 Abstract Views, 3 File Downloads  -  Detailed Statistics Created: Mon, 08 Dec 2014, 13:09:07 EST

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