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Natural antioxidant biomolecules promises future nanomedicine based therapy for cataract

Sunkireddy, Pavan, Jha, Shashi Nath, Kanwar, Jagat R. and Yadav, Subhash C. 2013, Natural antioxidant biomolecules promises future nanomedicine based therapy for cataract, Colloids and surfaces b: biointerfaces, vol. 112, pp. 554-562, doi: 10.1016/j.colsurfb.2013.07.068.

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Title Natural antioxidant biomolecules promises future nanomedicine based therapy for cataract
Author(s) Sunkireddy, Pavan
Jha, Shashi Nath
Kanwar, Jagat R.ORCID iD for Kanwar, Jagat R. orcid.org/0000-0003-3728-9568
Yadav, Subhash C.
Journal name Colloids and surfaces b: biointerfaces
Volume number 112
Start page 554
End page 562
Total pages 9
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2013-12
ISSN 1873-4367
Keyword(s) Ayurvedic treatment
Carotenoids
Flavonoids
Nanoencapsulation.
Oxidative modification
Phase separation
Antioxidants
Cataract
Crystallins
Humans
Hydroxybenzoates
Lactoferrin
Medicine, Ayurvedic
Nanomedicine
Nanotechnology
Osmotic Pressure
Oxidation-Reduction
Phase Transition
Protein Conformation
Vitamins
Science & Technology
Life Sciences & Biomedicine
Physical Sciences
Technology
Biophysics
Chemistry, Physical
Materials Science, Biomaterials
Chemistry
Materials Science
Nanoencapsulation
Summary Cataract is an eye disease of major human concern and its prevention is important to control the global incidences of blindness. The emergence of cataract in the eye lens by strong UV radiation and growing pollution could be effectively reduced by natural antioxidant biomolecules such as flavonoids, phenolic acids, carotenoids and vitamins. This goal can be achieved either by direct external use of antioxidant biomolecules in the form of topical application as an eye drops, food supplements or through nanobiotechnology based formulation without any side effects. In this manuscript, we have discussed the mechanisms of cataract formation and the preventive role of different classes of natural antioxidant biomolecules. Further, role of nanobiotechnology to enhance therapeutic potential of these natural antioxidant molecules by enhancing solubility, stability, bioavailability and sustained release has been briefly discussed.
Language eng
DOI 10.1016/j.colsurfb.2013.07.068
Field of Research 119999 Medical and Health Sciences not elsewhere classified
0306 Physical Chemistry (Incl. Structural)
0903 Biomedical Engineering
0904 Chemical Engineering
Socio Economic Objective 929999 Health not elsewhere classified
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2013, Elsevier B.V.
Persistent URL http://hdl.handle.net/10536/DRO/DU:30067545

Document type: Journal Article
Collection: School of Medicine
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