The global burden of musculoskeletal conditions for 2010: an overview of methods.

Hoy,DG, Smith,E, Cross,M, Sanchez-Riera,L, Buchbinder,R, Blyth,FM, Brooks,P, Woolf,AD, Osborne,RH, Fransen,M, Driscoll,T, Vos,T, Blore,JD, Murray,C, Johns,N, Naghavi,M, Carnahan,E and March,LM 2014, The global burden of musculoskeletal conditions for 2010: an overview of methods., Annals of the Rheumatic Diseases, vol. 73, no. 6, pp. 982-989, doi: 10.1136/annrheumdis-2013-204344.

Attached Files
Name Description MIMEType Size Downloads

Title The global burden of musculoskeletal conditions for 2010: an overview of methods.
Author(s) Hoy,DG
Osborne,RHORCID iD for Osborne,RH
Journal name Annals of the Rheumatic Diseases
Volume number 73
Issue number 6
Start page 982
End page 989
Total pages 10
Publisher BMJ Publishing Group
Place of publication England, London
Publication date 2014-06
ISSN 1468-2060
Keyword(s) Arthritis
Health services research
Outcomes research
Science & Technology
Life Sciences & Biomedicine
Summary The objective of this paper is to provide an overview of methods used for estimating the burden from musculoskeletal (MSK) conditions in the Global Burden of Diseases 2010 study. It should be read in conjunction with the disease-specific MSK papers published in Annals of Rheumatic Diseases. Burden estimates (disability-adjusted life years (DALYs)) were made for five specific MSK conditions: hip and/or knee osteoarthritis (OA), low back pain (LBP), rheumatoid arthritis (RA), gout and neck pain, and an 'other MSK conditions' category. For each condition, the main disabling sequelae were identified and disability weights (DW) were derived based on short lay descriptions. Mortality (years of life lost (YLLs)) was estimated for RA and the rest category of 'other MSK', which includes a wide range of conditions such as systemic lupus erythematosus, other autoimmune diseases and osteomyelitis. A series of systematic reviews were conducted to determine the prevalence, incidence, remission, duration and mortality risk of each condition. A Bayesian meta-regression method was used to pool available data and to predict prevalence values for regions with no or scarce data. The DWs were applied to prevalence values for 1990, 2005 and 2010 to derive years lived with disability. These were added to YLLs to quantify overall burden (DALYs) for each condition. To estimate the burden of MSK disease arising from risk factors, population attributable fractions were determined for bone mineral density as a risk factor for fractures, the occupational risk of LBP and elevated body mass index as a risk factor for LBP and OA. Burden of Disease studies provide pivotal guidance for governments when determining health priority areas and allocating resources. Rigorous methods were used to derive the increasing global burden of MSK conditions.
Language eng
DOI 10.1136/annrheumdis-2013-204344
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 920599 Specific Population Health (excl. Indigenous Health) not elsewhere classified
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2014, BMJ Publishing Group
Persistent URL

Document type: Journal Article
Collections: Faculty of Health
School of Health and Social Development
Connect to link resolver
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 65 times in TR Web of Science
Scopus Citation Count Cited 75 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 392 Abstract Views, 4 File Downloads  -  Detailed Statistics
Created: Mon, 05 Jan 2015, 09:03:21 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact