Fish oil diet associated with acute reperfusion related hemorrhage, and with reduced stroke-related sickness behaviors and motor impairment Pascoe, Michaela C, Howells, David W, Crewther, David P, Constantinou, Nicki, Carey, Leeanne M, Rewell, Sarah S, Turchini, Giovanni M, Kaur, Gunveen and Crewther, Sheila G 2014, Fish oil diet associated with acute reperfusion related hemorrhage, and with reduced stroke-related sickness behaviors and motor impairment, Frontiers in Neurology, vol. 5, Article number: 14, pp. 1-15, doi: 10.3389/fneur.2014.00014. Attached Files Name Description MIMEType Size Downloads pascoe-fishoil-2014.pdf Published version application/pdf 2.39MB 75 Title Fish oil diet associated with acute reperfusion related hemorrhage, and with reduced stroke-related sickness behaviors and motor impairment Author(s) Pascoe, Michaela C Howells, David W Crewther, David P Constantinou, Nicki Carey, Leeanne M Rewell, Sarah S Turchini, Giovanni M orcid.org/0000-0003-0694-4283 Kaur, Gunveen orcid.org/0000-0002-6250-0495 Crewther, Sheila G Journal name Frontiers in Neurology Volume number 5 Season Article number: 14 Start page 1 End page 15 Total pages 15 Publisher Frontiers Place of publication Lausanne, Switzerland Publication date 2014 ISSN 1664-2295 Keyword(s) middle-cerebral-artery-occlusion mood polyunsaturated fatty acids stroke Summary Ischemic stroke is associated with motor impairment and increased incidence of affective disorders such as anxiety/clinical depression. In non-stroke populations, successful management of such disorders and symptoms has been reported following diet supplementation with long chain omega-3-polyunsaturated-fatty-acids (PUFAs). However, the potential protective effects of PUFA supplementation on affective behaviors after experimentally induced stroke and sham surgery have not been examined previously. This study investigated the behavioral effects of PUFA supplementation over a 6-week period following either middle cerebral artery occlusion or sham surgery in the hooded-Wistar rat. The PUFA diet supplied during the acclimation period prior to surgery was found to be associated with an increased risk of acute hemorrhage following the reperfusion component of the surgery. In surviving animals, PUFA supplementation did not influence infarct size as determined 6 weeks after surgery, but did decrease omega-6-fatty-acid levels, moderate sickness behaviors, acute motor impairment, and longer-term locomotor hyperactivity and depression/anxiety-like behavior. Language eng DOI 10.3389/fneur.2014.00014 Field of Research 111104 Public Nutrition Intervention Socio Economic Objective 920199 Clinical Health (Organs, Diseases and Abnormal Conditions) not elsewhere classified HERDC Research category C1 Refereed article in a scholarly journal ERA Research output type C Journal article Copyright notice ©2014, The Authors Free to Read? Yes Use Rights Persistent URL http://hdl.handle.net/10536/DRO/DU:30067975 Document type: Journal Article Collections: Faculty of Health School of Psychology Faculty of Science, Engineering and Built Environment School of Life and Environmental Sciences Open Access Collection Related Links Link Description Connect to published version Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au. Versions Version Filter Type Mon, 01 Dec 2014, 17:52:13 EST Mon, 01 Dec 2014, 17:53:15 EST Tue, 02 Dec 2014, 04:00:49 EST Tue, 02 Dec 2014, 07:20:58 EST Mon, 23 Mar 2015, 10:37:48 EST Thu, 09 Apr 2015, 06:05:05 EST Thu, 09 Apr 2015, 10:34:03 EST Thu, 09 Apr 2015, 10:38:54 EST Mon, 18 Jul 2016, 15:31:27 EST Fri, 26 Aug 2016, 15:18:44 EST Mon, 05 Sep 2016, 16:06:29 EST Wed, 07 Sep 2016, 08:04:44 EST Fri, 10 Mar 2017, 13:45:43 EST Fri, 07 Sep 2018, 12:28:46 EST Filtered Full Citation counts:   Cited 6 times in TR Web of Science Cited 6 times in Scopus Search Google Scholar Access Statistics: 440 Abstract Views, 76 File Downloads  -  Detailed Statistics Created: Mon, 01 Dec 2014, 17:53:15 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.