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Fish oil diet associated with acute reperfusion related hemorrhage, and with reduced stroke-related sickness behaviors and motor impairment

Pascoe, Michaela C, Howells, David W, Crewther, David P, Constantinou, Nicki, Carey, Leeanne M, Rewell, Sarah S, Turchini, Giovanni M, Kaur, Gunveen and Crewther, Sheila G 2014, Fish oil diet associated with acute reperfusion related hemorrhage, and with reduced stroke-related sickness behaviors and motor impairment, Frontiers in Neurology, vol. 5, Article number: 14, pp. 1-15, doi: 10.3389/fneur.2014.00014.

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Title Fish oil diet associated with acute reperfusion related hemorrhage, and with reduced stroke-related sickness behaviors and motor impairment
Author(s) Pascoe, Michaela C
Howells, David W
Crewther, David P
Constantinou, Nicki
Carey, Leeanne M
Rewell, Sarah S
Turchini, Giovanni MORCID iD for Turchini, Giovanni M orcid.org/0000-0003-0694-4283
Kaur, Gunveen
Crewther, Sheila G
Journal name Frontiers in Neurology
Volume number 5
Season Article number: 14
Start page 1
End page 15
Total pages 15
Publisher Frontiers
Place of publication Lausanne, Switzerland
Publication date 2014
ISSN 1664-2295
Keyword(s) middle-cerebral-artery-occlusion
mood
polyunsaturated fatty acids
stroke
Summary Ischemic stroke is associated with motor impairment and increased incidence of affective disorders such as anxiety/clinical depression. In non-stroke populations, successful management of such disorders and symptoms has been reported following diet supplementation with long chain omega-3-polyunsaturated-fatty-acids (PUFAs). However, the potential protective effects of PUFA supplementation on affective behaviors after experimentally induced stroke and sham surgery have not been examined previously. This study investigated the behavioral effects of PUFA supplementation over a 6-week period following either middle cerebral artery occlusion or sham surgery in the hooded-Wistar rat. The PUFA diet supplied during the acclimation period prior to surgery was found to be associated with an increased risk of acute hemorrhage following the reperfusion component of the surgery. In surviving animals, PUFA supplementation did not influence infarct size as determined 6 weeks after surgery, but did decrease omega-6-fatty-acid levels, moderate sickness behaviors, acute motor impairment, and longer-term locomotor hyperactivity and depression/anxiety-like behavior.
Language eng
DOI 10.3389/fneur.2014.00014
Field of Research 111104 Public Nutrition Intervention
Socio Economic Objective 920199 Clinical Health (Organs, Diseases and Abnormal Conditions) not elsewhere classified
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2014, The Authors
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30067975

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Created: Mon, 01 Dec 2014, 17:53:15 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.