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Are urinary porphyrins a valid diagnostic biomarker of autism spectrum disorder?

Shandley,K, Austin,DW and Bhowmik,JL 2014, Are urinary porphyrins a valid diagnostic biomarker of autism spectrum disorder?, Autism research, vol. 7, no. 5, pp. 535-542, doi: 10.1002/aur.1385.

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Title Are urinary porphyrins a valid diagnostic biomarker of autism spectrum disorder?
Author(s) Shandley,K
Austin,DWORCID iD for Austin,DW orcid.org/0000-0002-1296-3555
Bhowmik,JL
Journal name Autism research
Volume number 7
Issue number 5
Start page 535
End page 542
Publisher Wiley Periodicals
Place of publication Malden, MA
Publication date 2014-10
ISSN 1939-3806
Keyword(s) ASD diagnosis
ASD severity
biomarker
heavy metals
mercury
porphyrins
Science & Technology
Social Sciences
Life Sciences & Biomedicine
Behavioral Sciences
Psychology, Developmental
Psychology
OXIDATIVE STRESS
NORMAL-CHILDREN
COPROPORPHYRINOGEN OXIDASE
ENVIRONMENTAL TOXICITY
EXCRETION
PREVALENCE
EXPOSURE
MARKER
Summary A fundamental challenge to the timely diagnosis of Autism Spectrum Disorder (ASD) is the reliance on the observation of a set of aberrant behavior. Consequently, the diagnostic process requires that the child reach an age where the behaviors would typically be exhibited. The identification of a reliable biological marker (biomarker) could be of considerable benefit to the diagnostic process. As a diagnostic biomarker, porphyrins present an attractive prospect as previous studies have reported consistent findings of children with ASD showing significant elevations in porphyrin levels in contrast to controls. Furthermore, there is some evidence that ASD severity may be associated with porphyrins, which would be a valuable characteristic of any ASD biomarker. Importantly, for practical use, porphyrins can be tested non-invasively via a sample of urine. The present study sought to investigate whether porphyrin profiles can reliably be used to (a) differentiate ASD cases from healthy controls; and (b) predict ASD severity. The study compared the porphyrin levels of three groups of children aged 2-6 years: Group 1-children diagnosed with ASD (n = 70); Group 2-healthy, normally developing siblings of children diagnosed with ASD (n = 36); and Group 3-healthy, normally developing children with no known blood relative diagnosed with ASD (n = 54). The results of logistic regression analyses failed to find support for the hypotheses that porphyrin levels could be used as a valid tool to detect ASD cases or predict severity. Autism Res 2014, 7: 535-542. © 2014 International Society for Autism Research, Wiley Periodicals, Inc.
Language eng
DOI 10.1002/aur.1385
Field of Research 170106 Health, Clinical and Counselling Psychology
Socio Economic Objective 920410 Mental Health
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2014, Wiley
Persistent URL http://hdl.handle.net/10536/DRO/DU:30067986

Document type: Journal Article
Collection: School of Psychology
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Created: Tue, 09 Dec 2014, 12:52:57 EST

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