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Young adult sequelae of adolescent cannabis use: an integrative analysis

Silins,E, Horwood,JL, Patton,GC, Fergusson,DM, Olsson,CA, Hutchinson,DM, Spry,E, Toumbourou,JW, Degenhardt,L, Swift,W, Coffey,C, Tait,RJ, Letcher,P, Copeland,J and Mattick,RP 2014, Young adult sequelae of adolescent cannabis use: an integrative analysis, Lancet psychiatry, vol. 1, no. 4, pp. 286-293, doi: 10.1016/S2215-0366(14)70307-4.

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Title Young adult sequelae of adolescent cannabis use: an integrative analysis
Author(s) Silins,E
Horwood,JL
Patton,GC
Fergusson,DM
Olsson,CAORCID iD for Olsson,CA orcid.org/0000-0002-5927-2014
Hutchinson,DMORCID iD for Hutchinson,DM orcid.org/0000-0003-3221-7143
Spry,E
Toumbourou,JWORCID iD for Toumbourou,JW orcid.org/0000-0002-8431-3762
Degenhardt,L
Swift,W
Coffey,C
Tait,RJ
Letcher,P
Copeland,J
Mattick,RP
Journal name Lancet psychiatry
Volume number 1
Issue number 4
Start page 286
End page 293
Total pages 8
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2014-09
ISSN 2215-0366
Keyword(s) Science & Technology
Life Sciences & Biomedicine
Psychiatry
ILLICIT DRUG-USE
PSYCHOTIC SYMPTOMS
MENTAL-HEALTH
SUBSTANCE USE
CONSEQUENCES
RISK
DEPENDENCE
EXPOSURE
OUTCOMES
PEOPLE
Longitudinal
Summary  Background: Debate continues about the consequences of adolescent cannabis use. Existing data are limited in statistical power to examine rarer outcomes and less common, heavier patterns of cannabis use than those already investigated; furthermore, evidence has a piecemeal approach to reporting of young adult sequelae. We aimed to provide a broad picture of the psychosocial sequelae of adolescent cannabis use. Methods: We integrated participant-level data from three large, long-running longitudinal studies from Australia and New Zealand: the Australian Temperament Project, the Christchurch Health and Development Study, and the Victorian Adolescent Health Cohort Study. We investigated the association between the maximum frequency of cannabis use before age 17 years (never, less than monthly, monthly or more, weekly or more, or daily) and seven developmental outcomes assessed up to age 30 years (high-school completion, attainment of university degree, cannabis dependence, use of other illicit drugs, suicide attempt, depression, and welfare dependence). The number of participants varied by outcome (N=2537 to N=3765). Findings: We recorded clear and consistent associations and dose-response relations between the frequency of adolescent cannabis use and all adverse young adult outcomes. After covariate adjustment, compared with individuals who had never used cannabis, those who were daily users before age 17 years had clear reductions in the odds of high-school completion (adjusted odds ratio 0·37, 95% CI 0·20-0·66) and degree attainment (0·38, 0·22-0·66), and substantially increased odds of later cannabis dependence (17·95, 9·44-34·12), use of other illicit drugs (7·80, 4·46-13·63), and suicide attempt (6·83, 2·04-22·90). Interpretation: Adverse sequelae of adolescent cannabis use are wide ranging and extend into young adulthood. Prevention or delay of cannabis use in adolescence is likely to have broad health and social benefits. Efforts to reform cannabis legislation should be carefully assessed to ensure they reduce adolescent cannabis use and prevent potentially adverse developmental effects. Funding: Australian Government National Health and Medical Research Council. © 2014 Elsevier Ltd.
Language eng
DOI 10.1016/S2215-0366(14)70307-4
Field of Research 170102 Developmental Psychology and Ageing
170106 Health, Clinical and Counselling Psychology
111716 Preventive Medicine
Socio Economic Objective 920414 Substance Abuse
HERDC Research category C1 Refereed article in a scholarly journal
Grant ID NHMRC 1099700
Copyright notice ©2014, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30068137

Document type: Journal Article
Collections: Faculty of Health
School of Psychology
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