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Vascular contribution to metastasis

Sax,M, Plummer,PN, Mittal,V and Mellick,AS 2014, Vascular contribution to metastasis, Cancer forum, vol. 38, no. 2, 5, pp. 103-107.

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Title Vascular contribution to metastasis
Author(s) Sax,M
Plummer,PN
Mittal,V
Mellick,AS
Journal name Cancer forum
Volume number 38
Issue number 2
Season 5
Start page 103
End page 107
Publisher Cancer Council Australia
Place of publication Sydney, N.S.W.
Publication date 2014-07
ISSN 0311-306X
Summary It has been 40 years since Folkman's seminal paper [Cancer Res 1974. 34:2109-13], proposing the presence of a tumour associated angiogenic factor, which could be targeted as an anticancer therapy. There are currently a handful of drugs in trial or use that have been marketed as targeting angiogenesis. Unfortunately, the most widely used of these, bevacizumab (Avastin™, Roche), has met with limited success clinically. For this reason and based on a calculation of cost benefit, bevacizumab is now only publically subsidised for use in a limited range of solid tumours. That the contribution of vasculature to malignancy remains poorly understood is increasingly clear. At the same time, the traditional view that vascularisation is a passive participant in the process of malignancy, and that endothelium merely provides a conduit by which tumour cells spread, is being replaced with an understanding that vasculature is a key player in the process of metastasis. Furthermore, the identification of non-traditional sources of vasculature has complicated our understanding of the tumour endothelium as a unique population that can be simply targeted as an anticancer therapy. The following review seeks to provide an up-to-date view of vascular contribution to metastasis and implications for new vasculature-targeted anticancer treatments.
Language eng
Field of Research 111201 Cancer Cell Biology
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2014, Cancer Council Australia
Persistent URL http://hdl.handle.net/10536/DRO/DU:30068214

Document type: Journal Article
Collections: School of Medicine
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.