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Comparative analysis of caveolins in mouse and tammar wallaby: role in regulating mammary gland function.

Kuruppath,S, Sharp,JA, Lefevre,C, Murphy,RM and Nicholas,KR 2014, Comparative analysis of caveolins in mouse and tammar wallaby: role in regulating mammary gland function., Gene, vol. 552, no. 1, pp. 51-58, doi: 10.1016/j.gene.2014.09.012.

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Title Comparative analysis of caveolins in mouse and tammar wallaby: role in regulating mammary gland function.
Author(s) Kuruppath,S
Sharp,JAORCID iD for Sharp,JA orcid.org/0000-0002-4481-5223
Lefevre,C
Murphy,RM
Nicholas,KR
Journal name Gene
Volume number 552
Issue number 1
Start page 51
End page 58
Total pages 8
Publisher Elsevier
Place of publication Amsterdam , Netherlands
Publication date 2014-11-15
ISSN 1879-0038
Keyword(s) Caveolin
Hormones
Lactation
Mammary gland
Mouse
Tammar wallaby
Science & Technology
Life Sciences & Biomedicine
Genetics & Heredity
CASEIN MESSENGER-RNA
TRANS-GOLGI-NETWORK
MACROPUS-EUGENII
EPITHELIAL-CELLS
SCAFFOLDING DOMAIN
GENE-EXPRESSION
GROWTH-FACTORS
IN-VITRO
PROTEIN
Summary Recent studies using the mouse showed an inverse correlation between the Caveolin 1 gene expression and lactation, and this was regulated by prolactin. However, current study using mammary explants from pregnant mice showed that while insulin (I), cortisol (F) and prolactin (P) resulted in maximum induction of the β-casein gene, FP and IFP resulted in the downregulation of Caveolin 1. Additionally, IF, FP and IFP resulted in the downregulation of Caveolin 2. Immunohistochemistry confirmed localisation of Caveolin 1 specific to myoepithelial cells and adipocytes. Comparative studies with the tammar wallaby showed Caveolin 1 and 2 had 70-80% homology with the mouse proteins. However, in contrast to the mouse, Caveolin 1 and 2 genes showed a significantly increased level of expression in the mammary gland during lactation. The regulation of tammar Caveolin 1 and 2 gene expression was examined in mammary explants from pregnant tammars, and no significant difference was observed either in the absence or in the presence of IFP.
Language eng
DOI 10.1016/j.gene.2014.09.012
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 929999 Health not elsewhere classified
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2014, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30068280

Document type: Journal Article
Collection: School of Medicine
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Created: Thu, 18 Dec 2014, 11:03:41 EST

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