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Paraoxonase (PON)1 Q192R functional genotypes and PON1 Q192R genotype by smoking interactions are risk factors for the metabolic syndrome, but not overweight or obesity

Bortolasci,CC, Vargas,HO, Souza-Nogueira,A, Gastaldello Moreira,E, Vargas Nunes,SO, Berk,M, Dodd,S, Barbosa,DS and Maes,M 2014, Paraoxonase (PON)1 Q192R functional genotypes and PON1 Q192R genotype by smoking interactions are risk factors for the metabolic syndrome, but not overweight or obesity, Redox report, vol. 19, no. 6, pp. 232-241, doi: 10.1179/1351000214Y.0000000093.

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Title Paraoxonase (PON)1 Q192R functional genotypes and PON1 Q192R genotype by smoking interactions are risk factors for the metabolic syndrome, but not overweight or obesity
Author(s) Bortolasci,CC
Vargas,HO
Souza-Nogueira,A
Gastaldello Moreira,E
Vargas Nunes,SO
Berk,MORCID iD for Berk,M orcid.org/0000-0002-5554-6946
Dodd,SORCID iD for Dodd,S orcid.org/0000-0002-7918-4636
Barbosa,DS
Maes,M
Journal name Redox report
Volume number 19
Issue number 6
Start page 232
End page 241
Publisher Maney Publishing
Place of publication Leeds, England
Publication date 2014-11
ISSN 1351-0002
1743-2928
Keyword(s) Cardiovascular
Depression
HDL cholesterol
Metabolic syndrome
Oxidative stress
Paraoxonase 1
Science & Technology
Life Sciences & Biomedicine
Biochemistry & Molecular Biology
MYOCARDIAL-INFARCTION RISK
CARDIOVASCULAR RISK
GENE POLYMORPHISMS
MAJOR DEPRESSION
ANTIOXIDANT PARAOXONASE-1
NICOTINE DEPENDENCE
HEART-DISEASE
ASSOCIATION
DISORDER
Summary Background The metabolic syndrome (MetS) is a complex of multiple risk factors that contribute to the onset of cardiovascular disorder, including lowered levels of high-density lipoprotein (HDL) and abdominal obesity. Smoking, mood disorders, and oxidative stress are associated with the MetS. Paraoxonase (PON)1 is an antioxidant bound to HDL, that is under genetic control by functional polymorphisms in the PON1 Q192R coding sequence. Aims and methods This study aimed to delineate the associations of the MetS with plasma PON1 activity, PON1 Q192R genotypes, smoking, and mood disorders (major depression and bipolar disorder), while adjusting for HDL cholesterol, body mass index, age, gender, and sociodemographic data. We measured plasma PON1 activity and serum HDL cholesterol and determined PON1 Q192R genotypes through functional analysis in 335 subjects, consisting of 97 with and 238 without MetS. The severity of nicotine dependence was measured using the Fagerström Nicotine Dependence Scale. Results PON1 Q192R functional genotypes and PON1 Q192R genotypes by smoking interactions were associated with the MetS. The QQ and QR genotypes were protective against MetS while smoking increased metabolic risk in QQ carriers only. There were no significant associations between PON1 Q192R genotypes and smoking by genotype interactions and obesity or overweight, while body mass index significantly increased MetS risk. Smoking and especially severe nicotine dependence are significantly associated with the MetS although these effects were no longer significant after considering the effects of the smoking by PON1 Q192R genotype interaction. The MetS was not associated with mood disorders, major depression or bipolar disorder. Discussion PON1 Q192R genotypes and genotypes by smoking interactions are risk factors for the MetS that together with lowered HDL and increased body mass and age contribute to the MetS.
Language eng
DOI 10.1179/1351000214Y.0000000093
Field of Research 110107 Metabolic Medicine
Socio Economic Objective 920499 Public Health (excl. Specific Population Health) not elsewhere classified
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2014, Maney Publishing
Persistent URL http://hdl.handle.net/10536/DRO/DU:30068808

Document type: Journal Article
Collection: School of Medicine
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