Statin use and risk of depression: a Swedish national cohort study Redlich, Cassie, Berk, Michael, Williams, Lana J., Sundquist, Jan, Sundquist, Kristina and Li, Xinjun 2014, Statin use and risk of depression: a Swedish national cohort study, BMC Psychiatry, vol. 14, no. 348, pp. 1-9, doi: 10.1186/s12888-014-0348-y. Attached Files Name Description MIMEType Size Downloads redlich-statinuse-2014.pdf Published version application/pdf 8.10MB 36 Title Statin use and risk of depression: a Swedish national cohort study Author(s) Redlich, Cassie Berk, Michael orcid.org/0000-0002-5554-6946 Williams, Lana J. orcid.org/0000-0002-1377-1272 Sundquist, Jan Sundquist, Kristina Li, Xinjun Journal name BMC Psychiatry Volume number 14 Issue number 348 Start page 1 End page 9 Total pages 9 Publisher BioMed Central Place of publication London, Eng. Publication date 2014-12-04 ISSN 1471-244X Summary Background : Statin medications, used to prevent heart disease by reducing cholesterol, also reduce inflammation and protect against oxidative damage. As inflammation and oxidative stress occur in depression, there is interest in their potential to reduce depression risk. We investigated whether use of statin medications was associated with a change in the risk of developing depression in a very large Swedish national cohort (n¿=¿4,607,990).MethodsNational register data for adults ¿40yr was analyzed to obtain information about depression diagnoses and prescriptions of statin medications between 2006 and 2008. Associations were tested using logistic regression.ResultsUse of any statin was shown to reduce the odds of depression by 8% compared to individuals not using statin medications (OR¿=¿0.92, 95% CI, 0.89-0.96; p¿<¿0.001). Simvastatin had a protective effect (OR¿=¿0.93, 95% CI, 0.89-0.97; p¿=¿0.001), whereas atorvastatin was associated with increased risk of depression (OR¿=¿1.11, 95% CI, 1.01-1.22; p¿=¿0.032). There was a stepwise decrease in odds ratio with increasing age (OR¿¿¿40 years¿=¿0.95, OR¿¿¿50 years¿=¿0.91, OR¿¿¿60 years¿=¿0.85, OR¿¿¿70 years¿=¿0.81).ConclusionsThe use of any statin was associated with a reduction in risk of depression in individuals over the age of 40. Clarification of the strength of these protective effects, the clinical relevance of these effects and determination of which statins are most effective is needed. Language eng DOI 10.1186/s12888-014-0348-y Field of Research 110319 Psychiatry (incl Psychotherapy) Socio Economic Objective 920410 Mental Health HERDC Research category C1 Refereed article in a scholarly journal Copyright notice ©2014, BioMed Central Free to Read? Yes Use Rights Persistent URL http://hdl.handle.net/10536/DRO/DU:30068825 Document type: Journal Article Collections: Faculty of Health School of Medicine Open Access Collection Related Links Link Description Connect to published version Go to link with your DU access privileges   Author URL Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au. Versions Version Filter Type Tue, 06 Jan 2015, 13:48:54 EST Wed, 07 Jan 2015, 04:02:03 EST Mon, 12 Jan 2015, 13:27:22 EST Sat, 17 Jan 2015, 05:07:13 EST Fri, 30 Jan 2015, 08:48:45 EST Fri, 30 Jan 2015, 08:56:54 EST Mon, 12 Oct 2015, 15:47:20 EST Wed, 14 Oct 2015, 14:07:45 EST Thu, 17 Mar 2016, 12:53:05 EST Thu, 17 Mar 2016, 12:55:16 EST Fri, 26 Aug 2016, 15:19:43 EST Mon, 05 Sep 2016, 16:07:30 EST Wed, 07 Sep 2016, 08:11:39 EST Fri, 07 Sep 2018, 12:07:53 EST Filtered Full Citation counts:   Cited 20 times in TR Web of Science Cited 27 times in Scopus Search Google Scholar Access Statistics: 541 Abstract Views, 37 File Downloads  -  Detailed Statistics Created: Tue, 06 Jan 2015, 13:48:54 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.