Effects of 60-day bed rest with and without exercise on cellular and humoral immunological parameters

Hoff, Paula, Belavý, Daniel L, Huscher, Dorte, Lang, Annemarie, Hahne, Martin, Kuhlmey, Anne-Kathrin, Maschmeyer, Patrick, Armbrecht, Gabriele, Fitzner, Rudolf, Perschel, Frank H, Gaber, Timo, Burmester, Gerd-Rudiger, Straub, Rainer H, Felsenberg, Dieter and Buttgereit, Frank 2014, Effects of 60-day bed rest with and without exercise on cellular and humoral immunological parameters, Cellular and molecular immunology, vol. 12, pp. 483-492, doi: 10.1038/cmi.2014.106.

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Title Effects of 60-day bed rest with and without exercise on cellular and humoral immunological parameters
Author(s) Hoff, Paula
Belavý, Daniel LORCID iD for Belavý, Daniel L orcid.org/0000-0002-9307-832X
Huscher, Dorte
Lang, Annemarie
Hahne, Martin
Kuhlmey, Anne-Kathrin
Maschmeyer, Patrick
Armbrecht, Gabriele
Fitzner, Rudolf
Perschel, Frank H
Gaber, Timo
Burmester, Gerd-Rudiger
Straub, Rainer H
Felsenberg, Dieter
Buttgereit, Frank
Journal name Cellular and molecular immunology
Volume number 12
Start page 483
End page 492
Total pages 10
Publisher Nature Publishing Group
Place of publication London, Eng.
Publication date 2014-11-10
ISSN 2042-0226
Summary Exercise at regular intervals is assumed to have a positive effect on immune functions. Conversely, after spaceflight and under simulated weightlessness (e.g., bed rest), immune functions can be suppressed. We aimed to assess the effects of simulated weightlessness (Second Berlin BedRest Study; BBR2-2) on immunological parameters and to investigate the effect of exercise (resistive exercise with and without vibration) on these changes. Twenty-four physically and mentally healthy male volunteers (20-45 years) performed resistive vibration exercise (n=7), resistance exercise without vibration (n=8) or no exercise (n=9) within 60 days of bed rest. Blood samples were taken 2 days before bed rest, on days 19 and 60 of bed rest. Composition of immune cells was analyzed by flow cytometry. Cytokines and neuroendocrine parameters were analyzed by Luminex technology and ELISA/RIA in plasma. General changes over time were identified by paired t-test, and exercise-dependent effects by pairwise repeated measurements (analysis of variance (ANOVA)). With all subjects pooled, the number of granulocytes, natural killer T cells, hematopoietic stem cells and CD45RA and CD25 co-expressing T cells increased and the number of monocytes decreased significantly during the study; the concentration of eotaxin decreased significantly. Different impacts of exercise were seen for lymphocytes, B cells, especially the IgD(+) subpopulation of B cells and the concentrations of IP-10, RANTES and DHEA-S. We conclude that prolonged bed rest significantly impacts immune cell populations and cytokine concentrations. Exercise was able to specifically influence different immunological parameters. In summary, our data fit the hypothesis of immunoprotection by exercise and may point toward even superior effects by resistive vibration exercise.Cellular & Molecular Immunology advance online publication, 10 November 2014; doi:10.1038/cmi.2014.106.
Language eng
DOI 10.1038/cmi.2014.106
Field of Research 110699 Human Movement and Sports Science not elsewhere classified
Socio Economic Objective 920401 Behaviour and Health
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Persistent URL http://hdl.handle.net/10536/DRO/DU:30068860

Document type: Journal Article
Collection: School of Exercise and Nutrition Sciences
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