You are not logged in.
Openly accessible

Identification of MicroRNAs linked to regulators of muscle protein synthesis and regeneration in young and old skeletal muscle

Zacharewicz, Evelyn, Della Gatta, Paul, Reynolds, John, Garnham, Andrew, Crowley, Tamsyn, Russell, Aaron P. and Lamon, Severine 2014, Identification of MicroRNAs linked to regulators of muscle protein synthesis and regeneration in young and old skeletal muscle, PLoS One, vol. 9, no. 12, Article Number : e114009, pp. 1-25, doi: 10.1371/journal.pone.0114009.

Attached Files
Name Description MIMEType Size Downloads
zacharewicz-identificationof-2014.pdf Published version application/pdf 1.63MB 43

Title Identification of MicroRNAs linked to regulators of muscle protein synthesis and regeneration in young and old skeletal muscle
Author(s) Zacharewicz, Evelyn
Della Gatta, PaulORCID iD for Della Gatta, Paul orcid.org/0000-0003-2231-8370
Reynolds, John
Garnham, Andrew
Crowley, Tamsyn
Russell, Aaron P.ORCID iD for Russell, Aaron P. orcid.org/0000-0002-7323-9501
Lamon, SeverineORCID iD for Lamon, Severine orcid.org/0000-0002-3271-6551
Journal name PLoS One
Volume number 9
Issue number 12
Season Article Number : e114009
Start page 1
End page 25
Total pages 25
Publisher PLoS
Place of publication San Francisco, Calif.
Publication date 2014
ISSN 1932-6203
Summary Over the course of ageing there is a natural and progressive loss of skeletal muscle mass. The onset and progression of age-related muscle wasting is associated with an attenuated activation of Akt-mTOR signalling and muscle protein synthesis in response to anabolic stimuli such as resistance exercise. MicroRNAs (miRNAs) are novel and important post-transcriptional regulators of numerous cellular processes. The role of miRNAs in the regulation of muscle protein synthesis following resistance exercise is poorly understood. This study investigated the changes in skeletal muscle miRNA expression following an acute bout of resistance exercise in young and old subjects with a focus on the miRNA species predicted to target Akt-mTOR signalling.
Language eng
DOI 10.1371/journal.pone.0114009
Field of Research 110699 Human Movement and Sports Science not elsewhere classified
Socio Economic Objective 920116 Skeletal System and Disorders (incl. Arthritis)
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2014, PLoS
Persistent URL http://hdl.handle.net/10536/DRO/DU:30068982

Connect to link resolver
 
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.

Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 22 times in TR Web of Science
Scopus Citation Count Cited 23 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 150 Abstract Views, 44 File Downloads  -  Detailed Statistics
Created: Tue, 13 Jan 2015, 12:59:54 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.