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Case report of interstitial nephritis induced by bevacizumab therapy for glioblastoma multiforme

Lomax, Anna J., Hill, Prue A. and Ashley, David M. 2013, Case report of interstitial nephritis induced by bevacizumab therapy for glioblastoma multiforme, Journal of oncology pharmacy practice, vol. 19, no. 4, pp. 365-368, doi: 10.1177/1078155212466421.

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Title Case report of interstitial nephritis induced by bevacizumab therapy for glioblastoma multiforme
Author(s) Lomax, Anna J.
Hill, Prue A.
Ashley, David M.
Journal name Journal of oncology pharmacy practice
Volume number 19
Issue number 4
Start page 365
End page 368
Total pages 4
Publisher Sage Publications
Place of publication London, Eng.
Publication date 2013-12
ISSN 1078-1552
1477-092X
Keyword(s) Glioblastoma multiforme
bevacizumab
interstitial nephritis
renal failure
vascular endothelial growth factor inhibitor
Angiogenesis Inhibitors
Antibodies, Monoclonal, Humanized
Biopsy
Brain Neoplasms
Glioblastoma
Glucocorticoids
Humans
Male
Middle Aged
Neoplasm Recurrence, Local
Nephritis, Interstitial
Summary Glioblastoma multiforme is an aggressive malignant brain tumor. The monoclonal antibody, bevacizumab, is active in recurrent disease via inhibition of angiogenesis. Proteinuria and renal thrombotic microangiopathy are known complications. We report a case of a patient developing acute renal failure with biopsy-proven interstitial nephritis while receiving bevacizumab for recurrent disease. The patient was otherwise well with a history of controlled hypertension. Renal function improved with discontinuation of bevacizumab and the administration of corticosteroid therapy.
Language eng
DOI 10.1177/1078155212466421
Field of Research 110904 Neurology and Neuromuscular Diseases
1115 Pharmacology And Pharmaceutical Sciences
Socio Economic Objective 920102 Cancer and Related Disorders
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2012, The Author(s)
Persistent URL http://hdl.handle.net/10536/DRO/DU:30069112

Document type: Journal Article
Collection: School of Medicine
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