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Protocol and rationale-the efficacy of minocycline as an adjunctive treatment for major depressive disorder: a double blind, randomised, placebo controlled trial

Dean,OM, Maes,M, Ashton,M, Berk,L, Kanchanatawan,B, Sughondhabirom,A, Tangwongchai,S, Ng,C, Dowling,N, Malhi,GS and Berk,M 2014, Protocol and rationale-the efficacy of minocycline as an adjunctive treatment for major depressive disorder: a double blind, randomised, placebo controlled trial, Clinical psychopharmacology and neuroscience, vol. 12, no. 3, pp. 180-188, doi: 10.9758/cpn.2014.12.3.180.

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Title Protocol and rationale-the efficacy of minocycline as an adjunctive treatment for major depressive disorder: a double blind, randomised, placebo controlled trial
Author(s) Dean,OMORCID iD for Dean,OM orcid.org/0000-0002-2776-3935
Maes,M
Ashton,MORCID iD for Ashton,M orcid.org/0000-0001-6832-4157
Berk,LORCID iD for Berk,L orcid.org/0000-0002-3677-7503
Kanchanatawan,B
Sughondhabirom,A
Tangwongchai,S
Ng,C
Dowling,N
Malhi,GS
Berk,MORCID iD for Berk,M orcid.org/0000-0002-5554-6946
Journal name Clinical psychopharmacology and neuroscience
Volume number 12
Issue number 3
Start page 180
End page 188
Total pages 9
Publisher Korean College of Neuropsychopharmacology
Place of publication Seoul, Korea
Publication date 2014-12
ISSN 1738-1088
Keyword(s) Clinical research protocol
Depression
Inflammation
Minocycline
Oxidative stress
Summary While current pharmacotherapies are efficacious, there remain a clear shortfall between symptom remission and functional recovery. With the explosion in our understanding of the biology of these disorders, the time is ripe for the investigation of novel therapies. Recently depression is conceptualized as an immune-inflammatory and nitro-oxidative stress related disorder. Minocycline is a tetracycline antibiotic that has anti-inflammatory, pro-oxidant, glutamatergic, neurotrophic and neuroprotective properties that make it a viable target to explore as a new therapy. This double blind, randomised, placebo controlled adjunctive trial will investigate the benefits of 200 mg/day of minocycline treatment, in addition to any usual treatment, as an adjunctive treatment for moderate-severe major depressive disorder. Sixty adults are being randomised to 12 weeks of treatment (with a 4 week follow-up post-discontinuation). The primary outcome measure for the study is mean change on the Montgomery-Asberg Depression Rating Scale (MADRS), with secondary outcomes including the Social and Occupational Functioning Assessment Scale (SOFAS), Clinical Global Impressions (CGI), Hamilton Rating Scale for Anxiety (HAM-A), Patient Global Impression (PGI), Quality of Life Enjoyment and Satisfaction Questionnaire (Q-LES-Q) and Range of Impaired Functioning Tool (LIFE-RIFT). Biomarker analyses will also be conducted at baseline and week 12. The study has the potential to provide new treatment targets, both by showing efficacy with a new class of 'antidepressant' but also through the analysis of biomarkers that may further inform our understanding of the pathophysiology of unipolar depression.
Language eng
DOI 10.9758/cpn.2014.12.3.180
Field of Research 111502 Clinical Pharmacology and Therapeutics
Socio Economic Objective 920410 Mental Health
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2014, Korean College of Neuropsychopharmacology
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30069371

Document type: Journal Article
Collections: School of Psychology
School of Medicine
Open Access Collection
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.