Ethanol as an alternative to formaldehyde for the enhancement of manganese(IV) chemiluminescence detection.

Smith,ZM, Terry,JM, Barnett,NW and Francis,PS 2014, Ethanol as an alternative to formaldehyde for the enhancement of manganese(IV) chemiluminescence detection., Talanta, vol. 130, pp. 221-225, doi: 10.1016/j.talanta.2014.07.002.

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Title Ethanol as an alternative to formaldehyde for the enhancement of manganese(IV) chemiluminescence detection.
Author(s) Smith,ZM
Terry,JM
Barnett,NW
Francis,PSORCID iD for Francis,PS orcid.org/0000-0003-4165-6922
Journal name Talanta
Volume number 130
Start page 221
End page 225
Total pages 5
Publisher Elsevier
Place of publication Amsterdam , Netherlands
Publication date 2014-12-01
ISSN 0039-9140
1873-3573
Keyword(s) Chemiluminescence
Disulfides
Flow injection analysis
High performance liquid chromatography
Manganese(IV)
Thiols
Science & Technology
Physical Sciences
Chemistry, Analytical
Chemistry
ACIDIC POTASSIUM-PERMANGANATE
SOLUBLE MANGANESE(IV)
REAGENT
Summary Previous applications of manganese(IV) as a chemiluminescence reagent have required the use of formaldehyde to enhance the emission intensity to analytically useful levels. However, this known human carcinogen (by inhalation) is not ideal for routine application. A wide range of alternative enhancers have been examined but to date none have been found to provide the dramatic increase in chemiluminescence intensities obtained using formaldehyde. Herein, we demonstrate that ethanol offers a simple, safe and inexpensive alternative to the use of formaldehyde for manganese(IV) chemiluminescence detection, without compromising signal intensity or sensitivity. For example, chemiluminescence signals for opiate alkaloids using 50-100% ethanol were 0.8-1.6-fold those using 2M formaldehyde. This innocuous alternative enhancer is shown to be a particularly effective for the direct detection of thiols and disulfides by manganese(IV) chemiluminescence, which we have applied to a simple HPLC procedure to determine a series of biomarkers of oxidative stress.
Language eng
DOI 10.1016/j.talanta.2014.07.002
Field of Research 030101 Analytical Spectrometry
030108 Separation Science
Socio Economic Objective 970103 Expanding Knowledge in the Chemical Sciences
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Grant ID DP14100439
Copyright notice ©2014, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30069423

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