Openly accessible

Design and rationale of a 16-week adjunctive randomized placebo-controlled trial of mitochondrial agents for the treatment of bipolar depression

Dean, Olivia M, Turner, Alyna, Malhi, Gin S, Ng, Chee, Cotton, Sue M, Dodd, Seetal, Sarris, Jarome, Samuni, Yuval, Tanious, Michelle, Dowling, Nathan, Waterdrinker, Astrid, Smith, Deidre and Berk, Michael 2015, Design and rationale of a 16-week adjunctive randomized placebo-controlled trial of mitochondrial agents for the treatment of bipolar depression, Revista Brasileira de psiquiatria, vol. 37, no. 1, pp. 3-12, doi: 10.1590/1516-4446-2013-1341.

Attached Files
Name Description MIMEType Size Downloads
dean-designandrationale-2015.pdf Published version application/pdf 208.66KB 13

Title Design and rationale of a 16-week adjunctive randomized placebo-controlled trial of mitochondrial agents for the treatment of bipolar depression
Author(s) Dean, Olivia MORCID iD for Dean, Olivia M orcid.org/0000-0002-2776-3935
Turner, AlynaORCID iD for Turner, Alyna orcid.org/0000-0001-7389-2546
Malhi, Gin S
Ng, Chee
Cotton, Sue M
Dodd, SeetalORCID iD for Dodd, Seetal orcid.org/0000-0002-7918-4636
Sarris, Jarome
Samuni, Yuval
Tanious, Michelle
Dowling, Nathan
Waterdrinker, Astrid
Smith, Deidre
Berk, MichaelORCID iD for Berk, Michael orcid.org/0000-0002-5554-6946
Journal name Revista Brasileira de psiquiatria
Volume number 37
Issue number 1
Start page 3
End page 12
Total pages 10
Publisher Associacao Brasileira de Psiquiatria
Place of publication Sao Paulo, Brazil
Publication date 2015-01
ISSN 1809-452X
Summary Objective: Bipolar disorder places a significant burden on individuals, caregivers and family, and the broader community. Current treatments are believed to be more effective against manic symptoms, leaving a shortfall in recovery during the depressive phase of the illness. The current study draws on recent evidence suggesting that, in addition to increased oxidative load, alterations in mitochondrial function occur in bipolar disorder.

Methods: This 16-week study aims to explore the potential benefits of N-acetylcysteine (NAC) alone or in combination (CT) with selected nutraceuticals believed to enhance mitochondrial function. The study includes adults diagnosed with bipolar disorder currently experiencing an episode of depression. Participants are asked to take NAC, CT, or placebo in addition to any usual treatments. A post-discontinuation visit is conducted 4 weeks following the treatment phase.

Results: The primary outcome of the study will be mean change on the Montgomery-Asberg Depression Rating Scale. Secondary outcomes include functioning, substance use, mania ratings, and quality of life. Blood samples will be collected at baseline and week 16 to explore biochemical alterations following treatment.

Conclusion: This study may provide a novel adjunctive treatment for bipolar depression. Analysis of biological samples may assist in understanding the therapeutic benefits and the underlying etiology of bipolar depression.
Language eng
DOI 10.1590/1516-4446-2013-1341
Field of Research 111714 Mental Health
Socio Economic Objective 920410 Mental Health
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2014, The Authors
Free to Read? Yes
Use Rights Creative Commons Attribution non-commercial licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30069431

Document type: Journal Article
Collections: School of Medicine
Open Access Collection
Connect to link resolver
 
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.

Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 19 times in TR Web of Science
Scopus Citation Count Cited 18 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 385 Abstract Views, 131 File Downloads  -  Detailed Statistics
Created: Thu, 05 Feb 2015, 13:33:07 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.