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Autonomous capillary microfluidic system with embedded optics for improved troponin I cardiac biomarker detection

Mohammed,MI and Desmulliez,MPY 2014, Autonomous capillary microfluidic system with embedded optics for improved troponin I cardiac biomarker detection, Biosensors and bioelectronics, vol. 61, pp. 478-484, doi: 10.1016/j.bios.2014.05.042.

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Title Autonomous capillary microfluidic system with embedded optics for improved troponin I cardiac biomarker detection
Author(s) Mohammed,MI
Desmulliez,MPY
Journal name Biosensors and bioelectronics
Volume number 61
Start page 478
End page 484
Publisher Elsevier BV
Place of publication Amsterdam, Netherlands
Publication date 2014-11-15
ISSN 0956-5663
Summary  Cardiovascular diseases are the most prevalent medical conditions affecting the modern world, reducing the quality of life for those affected and causing an ever increasing burden on clinical resources. Cardiac biomarkers are crucial in the diagnosis and management of patient outcomes. In that respect, such proteins are desirable to be measured at the point of care, overcoming the shortcomings of current instrumentation. We present a CO2 laser engraving technique for the rapid prototyping of a polymeric autonomous capillary system with embedded on-chip planar lenses and biosensing elements, the first step towards a fully miniaturised and integrated cardiac biosensing platform. The system has been applied to the detection of cardiac Troponin I, the gold standard biomarker for the diagnosis of acute myocardial infarction. The devised lab-on-a-chip device was demonstrated to have 24 pg/ml limit of detection, which is well within the minimum threshold for clinically applicable concentrations. Assays were completed within approximately 7–9 min. Initial results suggest that, given the portability, low power consumption and high sensitivity of the device, this technology could be developed further into point of care instrumentation useful in the diagnosis of various forms of cardiovascular diseases. 2014 Elsevier B.V. All rights reserved.
Language eng
DOI 10.1016/j.bios.2014.05.042
Field of Research 099999 Engineering not elsewhere classified
Socio Economic Objective 970109 Expanding Knowledge in Engineering
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2014, Elsevier BV
Persistent URL http://hdl.handle.net/10536/DRO/DU:30069548

Document type: Journal Article
Collection: School of Engineering
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