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Mind and body: how the health of the body impacts on neuropsychiatry

Renoir, Thibault, Hasebe, Kyoko and Gray, Laura 2013, Mind and body: how the health of the body impacts on neuropsychiatry, Frontiers in pharmacology, vol. 4, Article number: 145, pp. 1-16, doi: 10.3389/fphar.2013.00158.

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Title Mind and body: how the health of the body impacts on neuropsychiatry
Author(s) Renoir, Thibault
Hasebe, Kyoko
Gray, Laura
Journal name Frontiers in pharmacology
Volume number 4
Season Article number: 145
Start page 1
End page 16
Total pages 16
Publisher Frontiers Research Foundation
Place of publication Lausanne, Switzerland
Publication date 2013-12-18
ISSN 1663-9812
Keyword(s) HPA axis
inflammatory processes
mind-body interactions
mood disorders
peripheral disorders
psychiatric diseases
stress response
Science & Technology
Life Sciences & Biomedicine
Pharmacology & Pharmacy
MAJOR DEPRESSIVE DISORDER
CORONARY-HEART-DISEASE
PITUITARY-ADRENAL AXIS
TUMOR-NECROSIS-FACTOR
GLUCOCORTICOID-RECEPTOR GENE
CHRONIC HEPATITIS-C
N-3 FATTY-ACIDS
POSTMYOCARDIAL INFARCTION DEPRESSION
TREATMENT-RESISTANT DEPRESSION
FACTOR ANTAGONIST INFLIXIMAB
Summary It has long been established in traditional forms of medicine and in anecdotal knowledge that the health of the body and the mind are inextricably linked. Strong and continually developing evidence now suggests a link between disorders which involve Hypothalamic-Pituitary-Adrenal axis (HPA) dysregulation and the risk of developing psychiatric disease. For instance, adverse or excessive responses to stressful experiences are built into the diagnostic criteria for several psychiatric disorders, including depression and anxiety disorders. Interestingly, peripheral disorders such as metabolic disorders and cardiovascular diseases are also associated with HPA changes. Furthermore, many other systemic disorders associated with a higher incidence of psychiatric disease involve a significant inflammatory component. In fact, inflammatory and endocrine pathways seem to interact in both the periphery and the central nervous system (CNS) to potentiate states of psychiatric dysfunction. This review synthesizes clinical and animal data looking at interactions between peripheral and central factors, developing an understanding at the molecular and cellular level of how processes in the entire body can impact on mental state and psychiatric health.
Language eng
DOI 10.3389/fphar.2013.00158
Field of Research 110999 Neurosciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2013, The Authors
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30069617

Document type: Journal Article
Collections: School of Medicine
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.