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Medicine non-adherence in kidney transplantation

Williams,AF, Manias,E, Gaskin,CJ and Crawford,K 2014, Medicine non-adherence in kidney transplantation, Journal of Renal Care, vol. 40, no. 2, pp. 107-116, doi: 10.1111/jorc.12063.

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Title Medicine non-adherence in kidney transplantation
Author(s) Williams,AF
Manias,EORCID iD for Manias,E orcid.org/0000-0002-3747-0087
Gaskin,CJ
Crawford,K
Journal name Journal of Renal Care
Volume number 40
Issue number 2
Start page 107
End page 116
Total pages 10
Publisher Wiley-Blackwell
Place of publication Oxford, United Kingdom
Publication date 2014-06
ISSN 1755-6678
1755-6686
Keyword(s) Immunosuppression
Nursing
Self-management/self-care
Transplantation
Summary Background: The increasing prevalence of chronic kidney disease, the relative shortage of kidney donors and the economic- and health-related costs of kidney transplant rejection make the prevention of adverse outcomes following transplantation a healthcare imperative. Although strict adherence to immunosuppressant medicine regimens is key to preventing kidney rejection, evidence suggests that adherence is sub-optimal. Strategies need to be developed to help recipients of kidney transplants adhere to their prescribed medicines. Findings: This review has found that a number of factors contribute to poor adherence, for example, attitudes towards medicine taking and forgetfulness. Few investigations have been conducted, however, on strategies to enhance medicine adherence in kidney transplant recipients. Strategies that may improve adherence include pharmacist-led interventions (incorporating counselling, medicine reviews and nephrologist liaison) and nurse-led interventions (involving collaboratively working with recipients to understand their routines and offering solutions to improve adherence). Strategies that have shown to have limited effectiveness include supplying medicines free of charge and providing feedback on a participant's medicine adherence without any educational or behavioural interventions. Conclusion: Transplantation is the preferred treatment option for people with end-stage kidney disease. Medicine non-adherence in kidney transplantation increases the risk of rejection, kidney loss and costly treatments. Interventions are needed to help the transplant recipient take all their medicines as prescribed to improve general well-being, medicine safety and reduce healthcare costs. © 2014 European Dialysis and Transplant Nurses Association/European Renal Care Association.
Language eng
DOI 10.1111/jorc.12063
Field of Research 111099 Nursing not elsewhere classified
Socio Economic Objective 920201 Allied Health Therapies (excl. Mental Health Services)
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2014, Wiley-Blackwell
Persistent URL http://hdl.handle.net/10536/DRO/DU:30069628

Document type: Journal Article
Collection: School of Medicine
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