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Nuts 'n' guts: transport of food allergens across the intestinal epithelium

Price,Dwan, Ackland,L and Suphioglu,C 2013, Nuts 'n' guts: transport of food allergens across the intestinal epithelium, Asia Pacific allergy, vol. 3, no. 4, pp. 257-265, doi: 10.5415/apallergy.2013.3.4.257.

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Title Nuts 'n' guts: transport of food allergens across the intestinal epithelium
Author(s) Price,Dwan
Ackland,LORCID iD for Ackland,L orcid.org/0000-0002-7474-6556
Suphioglu,C
Journal name Asia Pacific allergy
Volume number 3
Issue number 4
Start page 257
End page 265
Total pages 9
Publisher Asia Pacific Association of Allergy, Asthma and Clinical Immunology
Place of publication Seoul, Korea
Publication date 2013-10
ISSN 2233-8276
Keyword(s) Cell barrier integrity
Cell tight junctions
Food allergy
Intestinal epithelial cell
Peanut
Peyer's patch
Summary The increase in the incidence of food allergy is a growing problem for the western world. This review will focus on the findings from several macromolecular epithelial transport experiments and drug permeability studies to provide a recent comprehension of food allergen intestinal epithelial cell transport and the allergen-epithelial relationship. Specifically, this review will aim to answer whether allergens can permeate the intestinal barrier directly via intestinal epithelial cells, and whether this mode of transport affects downstream immune reactions. By improving our understanding of the interactions which take place during exposure of food allergens with the intestinal epithelium, we can begin to understand whether the epithelial barrier plays a major role in the allergic sensitization process rather than simply restricting the entry of allergens to the underlying lamina propria.
Language eng
DOI 10.5415/apallergy.2013.3.4.257
Field of Research 110701 Allergy
Socio Economic Objective 920108 Immune System and Allergy
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2013, Asia Pacific allergy
Persistent URL http://hdl.handle.net/10536/DRO/DU:30069669

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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.