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Peptide-based biosensors

Liu, Qingtao, Wang, Jinfeng and Boyd, Ben J. 2015, Peptide-based biosensors, Talanta, vol. 136, pp. 114-127, doi: 10.1016/j.talanta.2014.12.020.

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Title Peptide-based biosensors
Author(s) Liu, Qingtao
Wang, JinfengORCID iD for Wang, Jinfeng orcid.org/0000-0002-2568-2170
Boyd, Ben J.
Journal name Talanta
Volume number 136
Start page 114
End page 127
Total pages 14
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2015-05-01
ISSN 0039-9140
Keyword(s) Biosensor
Fluorophore
Kinase
Peptides
Protease
Protein
Summary Peptides have been used as components in biological analysis and fabrication of novel biosensors for a number of reasons, including mature synthesis protocols, diverse structures and as highly selective substrates for enzymes. Bio-conjugation strategies can provide an efficient way to convert interaction information between peptides and analytes into a measurable signal, which can be used for fabrication of novel peptide-based biosensors. Many sensitive fluorophores can respond rapidly to environmental changes and stimuli manifest as a change in spectral characteristics, hence environmentally-sensitive fluorophores have been widely used as signal markers to conjugate to peptides to construct peptide-based molecular sensors. Additionally, nanoparticles, fluorescent polymers, graphene and near infrared dyes are also used as peptide-conjugated signal markers. On the other hand, peptides may play a generalist role in peptide-based biosensors. Peptides have been utilized as bio-recognition elements to bind various analytes including proteins, nucleic acid, bacteria, metal ions, enzymes and antibodies in biosensors. The selectivity of peptides as an enzymatic substrate has thus been utilized to construct enzyme sensors or enzyme-activity sensors. In addition, progress on immobilization and microarray techniques of peptides has facilitated the progress and commercial application of chip-based peptide biosensors in clinical diagnosis.
Language eng
DOI 10.1016/j.talanta.2014.12.020
Field of Research 111504 Pharmaceutical Sciences
Socio Economic Objective 920408 Health Status (e.g. Indicators of Well-Being)
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2015, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30069715

Document type: Journal Article
Collection: Institute for Frontier Materials
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