Using a selective cadmium-binding peplipid to create responsive liquid crystalline nanomaterials.

Liu, Qingtao, Wang, Jinfeng, Dong, Yao-Da and Boyd, Ben J. 2015, Using a selective cadmium-binding peplipid to create responsive liquid crystalline nanomaterials., Journal of colloid and interface science, vol. 449, pp. 122-129, doi: 10.1016/j.jcis.2014.11.063.

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Title Using a selective cadmium-binding peplipid to create responsive liquid crystalline nanomaterials.
Author(s) Liu, Qingtao
Wang, JinfengORCID iD for Wang, Jinfeng
Dong, Yao-Da
Boyd, Ben J.
Journal name Journal of colloid and interface science
Volume number 449
Start page 122
End page 129
Total pages 8
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2015-07-01
ISSN 1095-7103
Keyword(s) Lipid liquid crystalline
Metal ion
Phase transition
Summary A specific metal ion-responsive lipid liquid crystalline (LLC) dispersion system was fabricated, which can work in buffer solutions. The LLC matrix was prepared from phytantriol which spontaneously forms the reversed bicontinuous cubic phase in water, and a novel peptide-lipid conjugate (peplipid) consists of a myristate alkyl chain for anchoring into the phytantriol-based cubic bilayer and a peptide sequence for capturing a specific metal ion. The peplipid in its unbound state, when added into the phytantriol-based cubic system induces a positive effect on the bilayer curvature, resulting in the formation of the lamellar phase (vesicles) and the dispersion was transparent in appearance. Upon binding of the cadmium ion, the peplipid induces a negative effect on the lipid bilayer curvature and consequently leading to the formation of cubic phase and opaque appearance. In contrast, other metal ions, including buffering salts, could not sufficiently trigger the phase transition due to weak interaction with the peplipid. The high selectivity of metal ion interaction and triggered phase transition provide potential applications, such as in colloidal-mineral separation, triggered drug release and treatment of cadmium (II) pollution.
Language eng
DOI 10.1016/j.jcis.2014.11.063
Field of Research 111504 Pharmaceutical Sciences
Socio Economic Objective 920408 Health Status (e.g. Indicators of Well-Being)
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2014, Elsevier
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