Increased left hemisphere impairment in high-functioning autism : A tract based spatial statistics study

Perkins,TJ, Stokes,MA, McGillivray,JA, Mussap,AJ, Cox,IA, Maller,JJ and Bittar,RG 2014, Increased left hemisphere impairment in high-functioning autism : A tract based spatial statistics study, Psychiatry Research - Neuroimaging, vol. 224, no. 2, pp. 119-123, doi: 10.1016/j.pscychresns.2014.08.003.

Attached Files
Name Description MIMEType Size Downloads

Title Increased left hemisphere impairment in high-functioning autism : A tract based spatial statistics study
Author(s) Perkins,TJ
Stokes,MAORCID iD for Stokes,MA
McGillivray,JAORCID iD for McGillivray,JA
Mussap,AJORCID iD for Mussap,AJ
Journal name Psychiatry Research - Neuroimaging
Volume number 224
Issue number 2
Start page 119
End page 123
Total pages 5
Publisher Elsevier Ireland Ltd
Place of publication Shannon, County Clare, Ireland
Publication date 2014-11-30
ISSN 0925-4927
Keyword(s) Autism spectrum disorder
Diffusion Tensor Imaging
Fractional Anisotropy
Radial Diffusivity
Summary There is evidence emerging from Diffusion Tensor Imaging (DTI) research that autism spectrum disorders (ASD) are associated with greater impairment in the left hemisphere. Although this has been quantified with volumetric region of interest analyses, it has yet to be tested with white matter integrity analysis. In the present study, tract based spatial statistics was used to contrast white matter integrity of 12 participants with high-functioning autism or Aspergers syndrome (HFA/AS) with 12 typically developing individuals. Fractional Anisotropy (FA) was examined, in addition to axial, radial and mean diffusivity (AD, RD and MD). In the left hemisphere, participants with HFA/AS demonstrated significantly reduced FA in predominantly thalamic and fronto-parietal pathways and increased RD. Symmetry analyses confirmed that in the HFA/AS group, WM disturbance was significantly greater in the left compared to right hemisphere. These findings contribute to a growing body of literature suggestive of reduced FA in ASD, and provide preliminary evidence for RD impairments in the left hemisphere.
Language eng
DOI 10.1016/j.pscychresns.2014.08.003
Field of Research 170109 Personality, Abilities and Assessment
Socio Economic Objective 920499 Public Health (excl. Specific Population Health) not elsewhere classified
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2014, Elsevier Ireland Ltd
Persistent URL

Document type: Journal Article
Collection: School of Psychology
Connect to link resolver
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 8 times in TR Web of Science
Scopus Citation Count Cited 10 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 217 Abstract Views, 2 File Downloads  -  Detailed Statistics
Created: Thu, 19 Feb 2015, 14:23:38 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact