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Increased left hemisphere impairment in high-functioning autism : A tract based spatial statistics study

Perkins,TJ, Stokes,MA, McGillivray,JA, Mussap,AJ, Cox,IA, Maller,JJ and Bittar,RG 2014, Increased left hemisphere impairment in high-functioning autism : A tract based spatial statistics study, Psychiatry Research - Neuroimaging, vol. 224, no. 2, pp. 119-123, doi: 10.1016/j.pscychresns.2014.08.003.

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Title Increased left hemisphere impairment in high-functioning autism : A tract based spatial statistics study
Author(s) Perkins,TJ
Stokes,MAORCID iD for Stokes,MA orcid.org/0000-0001-6488-4544
McGillivray,JAORCID iD for McGillivray,JA orcid.org/0000-0003-2000-6488
Mussap,AJORCID iD for Mussap,AJ orcid.org/0000-0003-1290-3680
Cox,IA
Maller,JJ
Bittar,RG
Journal name Psychiatry Research - Neuroimaging
Volume number 224
Issue number 2
Start page 119
End page 123
Total pages 5
Publisher Elsevier Ireland Ltd
Place of publication Shannon, County Clare, Ireland
Publication date 2014-11-30
ISSN 0925-4927
1872-7506
Keyword(s) Autism spectrum disorder
Diffusion Tensor Imaging
Fractional Anisotropy
Radial Diffusivity
Summary There is evidence emerging from Diffusion Tensor Imaging (DTI) research that autism spectrum disorders (ASD) are associated with greater impairment in the left hemisphere. Although this has been quantified with volumetric region of interest analyses, it has yet to be tested with white matter integrity analysis. In the present study, tract based spatial statistics was used to contrast white matter integrity of 12 participants with high-functioning autism or Aspergers syndrome (HFA/AS) with 12 typically developing individuals. Fractional Anisotropy (FA) was examined, in addition to axial, radial and mean diffusivity (AD, RD and MD). In the left hemisphere, participants with HFA/AS demonstrated significantly reduced FA in predominantly thalamic and fronto-parietal pathways and increased RD. Symmetry analyses confirmed that in the HFA/AS group, WM disturbance was significantly greater in the left compared to right hemisphere. These findings contribute to a growing body of literature suggestive of reduced FA in ASD, and provide preliminary evidence for RD impairments in the left hemisphere.
Language eng
DOI 10.1016/j.pscychresns.2014.08.003
Field of Research 170109 Personality, Abilities and Assessment
Socio Economic Objective 920499 Public Health (excl. Specific Population Health) not elsewhere classified
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2014, Elsevier Ireland Ltd
Persistent URL http://hdl.handle.net/10536/DRO/DU:30069893

Document type: Journal Article
Collection: School of Psychology
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Created: Thu, 19 Feb 2015, 14:23:38 EST

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