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Theoretical modeling and experimental validation of surface stress in thrombin aptasensor

Lim,YC, Kouzani,AZ, Kaynak,A, Dai,XJ, Littlefair,G and Duan,W 2014, Theoretical modeling and experimental validation of surface stress in thrombin aptasensor, IEEE Transactions on Nanobioscience, vol. 13, no. 4, pp. 384-391, doi: 10.1109/TNB.2014.2337517.

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Title Theoretical modeling and experimental validation of surface stress in thrombin aptasensor
Author(s) Lim,YC
Kouzani,AZORCID iD for Kouzani,AZ orcid.org/0000-0002-6292-1214
Kaynak,A
Dai,XJ
Littlefair,G
Duan,WORCID iD for Duan,W orcid.org/0000-0001-5782-9184
Journal name IEEE Transactions on Nanobioscience
Volume number 13
Issue number 4
Start page 384
End page 391
Total pages 8
Publisher Institute of Electrical and Electronics Engineers Inc.
Place of publication Piscataway, N. J
Publication date 2014-12-01
ISSN 1558-2639
Keyword(s) Atomistic
continuum
intermolecular forces
mathematical model
microcantilever
surface stress
Science & Technology
Life Sciences & Biomedicine
Biochemical Research Methods
Nanoscience & Nanotechnology
Biochemistry & Molecular Biology
Science & Technology - Other Topics
SELF-ASSEMBLED MONOLAYERS
MICROCANTILEVER SENSORS
DNA
BINDING
PROTEINS
RECONSTRUCTION
NANOMECHANICS
HYBRIDIZATION
RECOGNITION
MOLECULES
Summary Adsorption of target molecules on the immobilized microcantilever surface produced beam displacement due to the differential surface stress generated between the immobilized and non-immobilized surface. Surface stress is caused by the intermolecular forces between the molecules. Van der Waals, electrostatic forces, hydrogen bonding, hydrophobic effect and steric hindrance are some of the intermolecular forces involved. A theoretical framework describing the adsorption-induced microcantilever displacement is derived in this paper. Experimental displacement of thrombin aptamer-thrombin interactions was carried out. The relation between the electrostatic interactions involved between adsorbates (thrombin) as well as adsorbates and substrates (thrombin aptamer) and the microcantilever beam displacement utilizing the proposed mathematical model was quantified and compared to the experimental value. This exercise is important to aid the designers in microcantilever sensing performance optimization.
Language eng
DOI 10.1109/TNB.2014.2337517
Field of Research 091306 Microelectromechanical Systems (MEMS)
Socio Economic Objective 861502 Medical Instruments
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2014, Institute of Electrical and Electronics Engineers Inc.
Persistent URL http://hdl.handle.net/10536/DRO/DU:30069941

Document type: Journal Article
Collection: School of Engineering
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