Novel immobilization of a quaternary ammonium moiety on keratin fibers for medical applications.

Yu,D, Cai,JY, Liu,X, Church,JS and Wang,L 2014, Novel immobilization of a quaternary ammonium moiety on keratin fibers for medical applications., International Journal of Biological Macromolecules, vol. 70, pp. 236-240, doi: 10.1016/j.ijbiomac.2014.06.025.

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Title Novel immobilization of a quaternary ammonium moiety on keratin fibers for medical applications.
Author(s) Yu,D
Liu,XORCID iD for Liu,X
Journal name International Journal of Biological Macromolecules
Volume number 70
Start page 236
End page 240
Publisher Elsevier
Place of publication Netherlands
Publication date 2014-09
ISSN 1879-0003
Keyword(s) Antibacterial
Keratin fiber
Quaternary ammonium
Science & Technology
Life Sciences & Biomedicine
Biochemistry & Molecular Biology
Summary This paper introduces a new approach for immobilizing a quaternary ammonium moiety on a keratinous substrate for enhanced medical applications. The method involves the generation of thiols by controlled reduction of cystine disulfide bonds in the keratin, followed by reaction with [2-(acryloyloxy)ethyl]trimethylammonium chloride through thiol-ene click chemistry. The modified substrate was characterized with Raman and infrared spectroscopy, and assessed for its antibacterial efficacy and other performance changes. The results have demonstrated that the quaternary ammonium moiety has been effectively attached onto the keratin structure, and the resultant keratin substrate exhibits a multifunctional effect including antibacterial and antistatic properties, improved liquid moisture management property, improved dyeability and a non-leaching characteristic of the treated substrate.
Language eng
DOI 10.1016/j.ijbiomac.2014.06.025
Field of Research 091205 Functional Materials
Socio Economic Objective 860401 Clothing
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2014, Elsevier
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Document type: Journal Article
Collections: Institute for Frontier Materials
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