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Green electrospun pantothenic acid/silk fibroin composite nanofibers: fabrication, characterization and biological activity

Fan,L, Cai,Z, Zhang,K, Han,F, Li,J, He,C, Mo,X, Wang,X and Wang,H 2014, Green electrospun pantothenic acid/silk fibroin composite nanofibers: fabrication, characterization and biological activity, Colloids and surfaces b: biointerfaces, vol. 117, pp. 14-20, doi: 10.1016/j.colsurfb.2013.12.030.

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Title Green electrospun pantothenic acid/silk fibroin composite nanofibers: fabrication, characterization and biological activity
Author(s) Fan,L
Cai,Z
Zhang,K
Han,F
Li,JORCID iD for Li,J orcid.org/0000-0003-0709-2246
He,C
Mo,X
Wang,X
Wang,H
Journal name Colloids and surfaces b: biointerfaces
Volume number 117
Start page 14
End page 20
Publisher Elsevier BV
Place of publication Amsterdam, Netherlands
Publication date 2014-05
ISSN 1873-4367
Keyword(s) Biomedical application
Composite nanofiber
Green electrospinning
Silk fibroin
Skin care product
Vitamin B(5)
Summary Silk fibroin (SF) from Bombyx mori has many established excellent properties and has found various applications in the biomedical field. However, some abilities or capacities of SF still need improving to meet the need for using practically. Indeed, diverse SF-based composite biomaterials have been developed. Here we report the feasibility of fabricating pantothenic acid (vitamin B5, VB5)-reinforcing SF nanofibrous matrices for biomedical applications through green electrospinning. Results demonstrated the successful loading of D-pantothenic acid hemicalcium salt (VB5-hs) into resulting composite nanofibers. The introduction of VB5-hs did not alter the smooth ribbon-like morphology and the silk I structure of SF, but significantly decreased the mean width of SF fibers. SF conformation transformed into β-sheet from random coil when composite nanofibrous matrices were exposed to 75% (v/v) ethanol vapor. Furthermore, nanofibers still remained good morphology after being soaked in water environment for five days. Interestingly, as-prepared composite nanofibrous matrices supported a higher level of cell viability, especially in a long culture period and significantly assisted skin cells to survive under oxidative stress compared with pure SF nanofibrous matrices. These findings provide a basis for further extending the application of SF in the biomedical field, especially in the personal skin-care field.
Language eng
DOI 10.1016/j.colsurfb.2013.12.030
Field of Research 090301 Biomaterials
091205 Functional Materials
Socio Economic Objective 920117 Skin and Related Disorders
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2014, Elsevier BV
Persistent URL http://hdl.handle.net/10536/DRO/DU:30070041

Document type: Journal Article
Collection: Institute for Frontier Materials
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