You are not logged in.

RAFT controlled synthesis of graphene/polymer hydrogel with enhanced mechanical property for pH-controlled drug release

Liu,J, Cui,L, Kong,N, Barrow,CJ and Yang,W 2014, RAFT controlled synthesis of graphene/polymer hydrogel with enhanced mechanical property for pH-controlled drug release, European polymer journal, vol. 50, no. 1, pp. 9-17, doi: 10.1016/j.eurpolymj.2013.10.015.

Attached Files
Name Description MIMEType Size Downloads

Title RAFT controlled synthesis of graphene/polymer hydrogel with enhanced mechanical property for pH-controlled drug release
Author(s) Liu,J
Cui,L
Kong,N
Barrow,CJORCID iD for Barrow,CJ orcid.org/0000-0002-2153-7267
Yang,WORCID iD for Yang,W orcid.org/0000-0001-8815-1951
Journal name European polymer journal
Volume number 50
Issue number 1
Start page 9
End page 17
Publisher Elsevier
Place of publication London, England
Publication date 2014-01
ISSN 0014-3057
1873-1945
Keyword(s) Controlled drug release
Diazonium salt
Graphene
pH sensitive hydrogel
RAFT polymerization
Science & Technology
Physical Sciences
Polymer Science
WALLED CARBON NANOTUBES
GRAPHITE OXIDE SHEETS
COMPOSITE HYDROGELS
POLYMER NANOCOMPOSITES
POLY(VINYL ALCOHOL)
FILMS
FUNCTIONALIZATION
CONDUCTIVITY
MOLECULES
MEDICINE
Summary A pH-sensitive, mechanically strong and thermally stable graphene/poly (acrylic acid) (graphene/PAA) hydrogel was prepared via reversible addition fragmentation transfer (RAFT) polymerizations in the presence of a cross-linking agent. The RAFT agent was covalently coupled onto graphene basal planes via an esterification reaction, with benzoic acid functionalities pre-attached on graphene with its aryl diazonium salt precursor. AFM and SEM analysis revealed the successful preparation of single layered graphene sheets and graphene/polymer hydrogels with pH controlled porous structures. Attenuated total reflection infrared (ATR-IR) and thermogravimetric analyzer (TGA) verified the successful stepwise preparation of graphene/PAA hydrogel. This graphene/PAA hydrogel was pH-sensitive and more mechanically elastic than the PAA hydrogel prepared without graphene. The pH sensitivity of the hydrogel was further utilized for controlled drug release. Doxorubicin was chosen as a model drug and loaded into the hydrogels. The drug loading and release experiment indicated that this hydrogel can be used to efficiently control drug release in the intestine environment (pH = 7.4), better than release in a more acidic environment.© 2013 Elsevier Ltd. All rights reserved.
Language eng
DOI 10.1016/j.eurpolymj.2013.10.015
Field of Research 030302 Nanochemistry and Supramolecular Chemistry
Socio Economic Objective 970103 Expanding Knowledge in the Chemical Sciences
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2014, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30070047

Connect to link resolver
 
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 25 times in TR Web of Science
Scopus Citation Count Cited 25 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 234 Abstract Views, 1 File Downloads  -  Detailed Statistics
Created: Wed, 25 Feb 2015, 16:12:52 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.