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Validation of DNA methylation biomarkers for diagnosis of acute lymphoblastic leukemia

Chatterton,Z, Burke,D, Emslie,KR, Craig,JM, Ng,J, Ashley,DM, Mechinaud,F, Saffery,R and Wong,NC 2014, Validation of DNA methylation biomarkers for diagnosis of acute lymphoblastic leukemia, Clinical chemistry, vol. 60, no. 7, pp. 995-1003, doi: 10.1373/clinchem.2013.219956.

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Title Validation of DNA methylation biomarkers for diagnosis of acute lymphoblastic leukemia
Author(s) Chatterton,Z
Burke,D
Emslie,KR
Craig,JM
Ng,J
Ashley,DM
Mechinaud,F
Saffery,R
Wong,NC
Journal name Clinical chemistry
Volume number 60
Issue number 7
Start page 995
End page 1003
Publisher American Society for Clinical Pathology
Place of publication Chicago, IL
Publication date 2014-07
ISSN 1530-8561
Keyword(s) Science & Technology
Life Sciences & Biomedicine
Medical Laboratory Technology
MINIMAL RESIDUAL DISEASE
PROMOTER HYPERMETHYLATION
MASS-SPECTROMETRY
CHILDHOOD
CANCER
GENE
INACTIVATION
MGMT
QUANTIFICATION
CHILDREN
Summary DNA methylation biomarkers capable of diagnosis and subtyping have been found for many cancers. Fifteen such markers have previously been identified for pediatric acute lymphoblastic leukemia (ALL). Validation of these markers is necessary to assess their clinical utility for molecular diagnostics. Substantial efficiencies could be achieved with these DNA methylation markers for disease tracking with potential to replace patient-specific genetic testing.
Language eng
DOI 10.1373/clinchem.2013.219956
Field of Research 111202 Cancer Diagnosis
111403 Paediatrics
111203 Cancer Genetics
Socio Economic Objective 920102 Cancer and Related Disorders
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2014, American Society for Clinical Pathology
Persistent URL http://hdl.handle.net/10536/DRO/DU:30070077

Document type: Journal Article
Collection: School of Medicine
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