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Fabrication of high specificity hollow mesoporous silica nanoparticles assisted by Eudragit for targeted drug delivery.

She,X, Chen,L, Velleman,L, Li,C, Zhu,H, He,C, Wang,T, Shigdar,S, Duan,W and Kong,L 2014, Fabrication of high specificity hollow mesoporous silica nanoparticles assisted by Eudragit for targeted drug delivery., Journal of Colloid and Interface Science, vol. 445, pp. 151-160, doi: 10.1016/j.jcis.2014.12.053.

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Title Fabrication of high specificity hollow mesoporous silica nanoparticles assisted by Eudragit for targeted drug delivery.
Author(s) She,X
Chen,L
Velleman,L
Li,C
Zhu,HORCID iD for Zhu,H orcid.org/0000-0001-6352-7633
He,C
Wang,T
Shigdar,S
Duan,W
Kong,LORCID iD for Kong,L orcid.org/0000-0001-6219-3897
Journal name Journal of Colloid and Interface Science
Volume number 445
Start page 151
End page 160
Publisher Elsevier
Place of publication United States
Publication date 2014-05
ISSN 1095-7103
Keyword(s) Eudragit assisted synthesis
Hollow mesoporous silica nanoparticles
Specificity
Targeted delivery
Summary Hollow mesoporous silica nanoparticles (HMSNs) are one of the most promising carriers for effective drug delivery due to their large surface area, high volume for drug loading and excellent biocompatibility. However, the non-ionic surfactant templated HMSNs often have a broad size distribution and a defective mesoporous structure because of the difficulties involved in controlling the formation and organization of micelles for the growth of silica framework. In this paper, a novel "Eudragit assisted" strategy has been developed to fabricate HMSNs by utilising the Eudragit nanoparticles as cores and to assist in the self-assembly of micelle organisation. Highly dispersed mesoporous silica spheres with intact hollow interiors and through pores on the shell were fabricated. The HMSNs have a high surface area (670m(2)/g), small diameter (120nm) and uniform pore size (2.5nm) that facilitated the effective encapsulation of 5-fluorouracil within HMSNs, achieving a high loading capacity of 194.5mg(5-FU)/g(HMSNs). The HMSNs were non-cytotoxic to colorectal cancer cells SW480 and can be bioconjugated with Epidermal Growth Factor (EGF) for efficient and specific cell internalization. The high specificity and excellent targeting performance of EGF grafted HMSNs have demonstrated that they can become potential intracellular drug delivery vehicles for colorectal cancers via EGF-EGFR interaction.
Language eng
DOI 10.1016/j.jcis.2014.12.053
Field of Research 090406 Powder and Particle Technology
Socio Economic Objective 860803 Human Pharmaceutical Treatments (e.g. Antibiotics)
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2015, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30070172

Document type: Journal Article
Collections: School of Medicine
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