Three-dimensional numerical simulation of blood flow in mouse aortic arch around atherosclerotic plaques

Assemat,P, Armitage,JA, Siu,KK, Contreras,KG, Dart,AM, Chin-Dusting,JP and Hourigan,K 2014, Three-dimensional numerical simulation of blood flow in mouse aortic arch around atherosclerotic plaques, Applied Mathematical Modelling, vol. 38, no. 17-18, pp. 4175-4185, doi: 10.1016/j.apm.2014.01.004.

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Title Three-dimensional numerical simulation of blood flow in mouse aortic arch around atherosclerotic plaques
Author(s) Assemat,P
Armitage,JAORCID iD for Armitage,JA
Journal name Applied Mathematical Modelling
Volume number 38
Issue number 17-18
Start page 4175
End page 4185
Total pages 11
Publisher Elsevier
Place of publication New York, United States
Publication date 2014-02-05
ISSN 0307-904X
Keyword(s) Atherosclerotic plaques
Mechanical effects
Oscillating flow
Plaque progression
Pressure gradient
Wall shear stress
Summary Atherosclerosis is a progressive disease, involving the build-up of lipid streaks in artery walls, leading to plaques. Understanding the development of atherosclerosis and plaque vulnerability is critically important since plaque rupture can result in heart attack or stroke. Plaques can be divided into two distinct types: those likely to rupture (vulnerable) or less likely to rupture (stable). In the last decade, researchers have been interested in studying the influence of the mechanical effects (blood shear stress, pressure forces and structural stress) on the plaque formation, progression and rupture processes but no general agreement has been found. The purpose of the present work is to include more realistic conditions for the numerical calculations of the blood flow by implementing real geometries with plaques in the numerical model. Hemodynamical parameters are studied in both diseased and healthy configurations. The healthy configuration is obtained by removing numerically the plaques from three dimensional geometries obtained by micro-computed tomography. A new hemodynamical parameter is also introduced to relate the location of plaques to the characteristics of the flow in the healthy configuration. © 2014 .
Language eng
DOI 10.1016/j.apm.2014.01.004
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 920101 Blood Disorders
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2014, Elsevier
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Document type: Journal Article
Collection: School of Medicine
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