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Short term fat feeding rapidly increases plasma insulin but does not result in dyslipidaemia

Barzel,B, Weir,JM, Meikle,PJ, Burke,SL, Armitage,JA and Head,GA 2014, Short term fat feeding rapidly increases plasma insulin but does not result in dyslipidaemia, Frontiers in Physiology, vol. 5, no. Nov, pp. 2-19, doi: 10.3389/fphys.2014.00469.

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Title Short term fat feeding rapidly increases plasma insulin but does not result in dyslipidaemia
Author(s) Barzel,B
Weir,JM
Meikle,PJ
Burke,SL
Armitage,JA
Head,GA
Journal name Frontiers in Physiology
Volume number 5
Issue number Nov
Start page 2
End page 19
Total pages 21
Publisher Frontiers Research Foundation
Place of publication Lausanne, Switzerland
Publication date 2014-11-15
ISSN 1664-042X
Keyword(s) Hypertension
Insulin
Leptin
Obesity
Plasma lipids
Summary Although the association between obesity and hypertension is well known, the underlying mechanism remains elusive. Previously, we have shown that 3 week fat feeding in rabbits produces greater visceral adiposity, hypertension, tachycardia and elevated renal sympathetic nerve activity compared to rabbits on a normal diet. Because hyperinsulinaemia, hyperleptinemia and dyslipidaemia are independent cardiovascular risk factors associated with hypertension we compared plasma insulin, leptin and lipid profiles in male New Zealand White rabbits fed a normal fat diet (NFD 4.3% fat, n = 11) or high fat diet (HFD 13.4% fat, n = 13) at days 1, 2, 3 and weeks 1, 2, 3 of the diet. Plasma concentrations of diacylglyceride (DG), triacylglyceride (TG), ceramide and cholesteryl esters (CE) were obtained after analysis by liquid chromatography mass spectrometry. Plasma insulin and glucose increased within the first 3 days of the diet in HFD rabbits (P <0.05) and remained elevated at week 1 (P <0.05). Blood pressure and heart rate followed a similar pattern. By contrast, in both groups, plasma leptin levels remained unchanged during the first few days (P >0.05), increasing by week 3 in fat fed animals alone (P <0.05). Concentrations of total DG, TG, CE and Ceramide at week 3 did not differ between groups (P >0.05). Our data show plasma insulin increases rapidly following consumption of a HFD and suggests that it may play a role in the rapid rise of blood pressure. Dyslipidaemia does not appear to contribute to the hypertension in this animal model.
Language eng
DOI 10.3389/fphys.2014.00469
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 929999 Health not elsewhere classified
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2014, Frontiers Research Foundation
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30070186

Document type: Journal Article
Collections: School of Medicine
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.