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Beta-lactam antibiotics as a possible novel therapy for managing epilepsy and autism, a case report and review of literature

Ghanizadeh, A. and Berk, M. 2015, Beta-lactam antibiotics as a possible novel therapy for managing epilepsy and autism, a case report and review of literature, Iranian Journal of Child Neurology, vol. 9, no. 1, pp. 99-102.

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Title Beta-lactam antibiotics as a possible novel therapy for managing epilepsy and autism, a case report and review of literature
Author(s) Ghanizadeh, A.
Berk, M.ORCID iD for Berk, M. orcid.org/0000-0002-5554-6946
Journal name Iranian Journal of Child Neurology
Volume number 9
Issue number 1
Start page 99
End page 102
Publisher Iranian Child Neurology Society
Publication date 2015-12-01
ISSN 1735-4668
2008-0700
Keyword(s) Antibiotic
Cefixime
Glutamate
Inflammation
Therapy
Transporter
Summary Autism is a disorder of unknown etiology. There are few FDA approved medications for treating autism. Co-occurring autism and epilepsy is common, and glutamate antagonists improve some symptoms of autism. Ceftriaxone, a beta-lactam antibiotic, increases the expression of the glutamate transporter 1 which decreases extracellular glutamate levels. It is hypothesized that modulating astrocyte glutamate transporter expression by ceftriaxone or cefixime might improve some symptoms of autism. This case report of a child with autism and epilepsy suggests a decrease in seizures after taking cefixime
Language eng
Field of Research 110319 Psychiatry (incl Psychotherapy)
Socio Economic Objective 920410 Mental Health
HERDC Research category C3 Non-refereed articles in a professional journal
Copyright notice ©2015, Iranian Child Neurology Society
Persistent URL http://hdl.handle.net/10536/DRO/DU:30070215

Document type: Journal Article
Collections: School of Medicine
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.