Phylogenetic analysis of beak and feather disease virus across a host ring-species complex

Eastwood,JR, Berg,ML, Ribot,RF, Raidal,SR, Buchanan,KL, Walder,KR and Bennett,AT 2014, Phylogenetic analysis of beak and feather disease virus across a host ring-species complex, Proceedings of the national scademy of sciences of the USA, vol. 111, no. 39, pp. 14153-14158, doi: 10.1073/pnas.1403255111.

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Title Phylogenetic analysis of beak and feather disease virus across a host ring-species complex
Author(s) Eastwood,JR
Berg,MLORCID iD for Berg,ML
Ribot,RFORCID iD for Ribot,RF
Buchanan,KLORCID iD for Buchanan,KL
Walder,KRORCID iD for Walder,KR
Bennett,ATORCID iD for Bennett,AT
Journal name Proceedings of the national scademy of sciences of the USA
Volume number 111
Issue number 39
Start page 14153
End page 14158
Publisher National Academy of Sciences
Place of publication Washington, DC
Publication date 2014-09-30
ISSN 1091-6490
Keyword(s) crimson rosella
host–pathogen coevolution
psittacine circovirus
sympatric speciation
Host-pathogen coevolution
Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
Summary Pathogens have been hypothesized to play a major role in host diversity and speciation. Susceptibility of hybrid hosts to pathogens is thought to be a common phenomenon that could promote host population divergence and subsequently speciation. However, few studies have tested for pathogen infection across animal hybrid zones while testing for codivergence of the pathogens in the hybridizing host complex. Over 8 y, we studied natural infection by a rapidly evolving single-strand DNA virus, beak and feather diseases virus (BFDV), which infects parrots, exploiting a host-ring species complex (Platycercus elegans) in Australia. We found that host subspecies and their hybrids varied strikingly in both BFDV prevalence and load: both hybrid and phenotypically intermediate subspecies had lower prevalence and load compared with parental subspecies, while controlling for host age, sex, longitude and latitude, as well as temporal effects. We sequenced viral isolates throughout the range, which revealed patterns of genomic variation analogous to Mayr's ring-species hypothesis, to our knowledge for the first time in any host-pathogen system. Viral phylogeny, geographic location, intraspecific host density, and parrot community diversity and composition did not explain the differences in BFDV prevalence or load between subpopulations. Overall, our analyses suggest that functional host responses to infection, or force of infection, differ between subspecies and hybrids. Our findings highlight the role of host hybridization and clines in altering host-pathogen interactions, dynamics that can have important implications for models of speciation with gene flow, and offer insights into how pathogens may adapt to diverging host populations.
Language eng
DOI 10.1073/pnas.1403255111
Field of Research 069999 Biological Sciences not elsewhere classified
Socio Economic Objective 929999 Health not elsewhere classified
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2014, National Academy of Science
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