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Peanut allergens alter intestinal barrier permeability and tight junction localisation in Caco-2 cell cultures

Price,DB, Ackland,ML, Burks,W, Knight,MI and Suphioglu,C 2014, Peanut allergens alter intestinal barrier permeability and tight junction localisation in Caco-2 cell cultures, Cellular Physiology and Biochemistry, vol. 33, no. 6, pp. 1758-1777, doi: 10.1159/000362956.

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Title Peanut allergens alter intestinal barrier permeability and tight junction localisation in Caco-2 cell cultures
Author(s) Price,DB
Ackland,MLORCID iD for Ackland,ML orcid.org/0000-0002-7474-6556
Burks,W
Knight,MI
Suphioglu,C
Journal name Cellular Physiology and Biochemistry
Volume number 33
Issue number 6
Start page 1758
End page 1777
Total pages 20
Publisher S. Karger AG
Place of publication Basel, Switzerland
Publication date 2014
ISSN 1421-9778
Keyword(s) Allergen
Caco-2
Epithelia
Peanut
Permeability
Tight junction
Transport
Science & Technology
Life Sciences & Biomedicine
Cell Biology
Physiology
ARA H 1
IGE-BINDING EPITOPES
COLORECTAL-CANCER CELLS
MAJOR SOYBEAN ALLERGEN
ADHESION MOLECULE
EPITHELIAL-CELLS
IN-VITRO
MUTATIONAL ANALYSIS
ENDOTHELIAL-CELLS
CHOLERA-TOXIN
Summary Allergen absorption by epithelia may play an important role in downstream immune responses. Transport mechanisms that can bypass Peyer's patches include transcellular and paracellular transport. The capacity of an allergen to cross via these means can modulate downstream processing of the allergen by the immune system. The aim of this study was to investigate allergen-epithelial interactions of peanut allergens with the human intestinal epithelium.
Language eng
DOI 10.1159/000362956
Field of Research 110799 Immunology not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2014, S. Karger AG
Persistent URL http://hdl.handle.net/10536/DRO/DU:30070301

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