Closed loop deep brain stimulation: an evolving technology

Hosain,MK, Kouzani,A and Tye,S 2014, Closed loop deep brain stimulation: an evolving technology, Australasian physical & engineering sciences in medicine, vol. 37, no. 4, pp. 619-634, doi: 10.1007/s13246-014-0297-2.

Attached Files
Name Description MIMEType Size Downloads

Title Closed loop deep brain stimulation: an evolving technology
Author(s) Hosain,MK
Kouzani,AORCID iD for Kouzani,A
Journal name Australasian physical & engineering sciences in medicine
Volume number 37
Issue number 4
Start page 619
End page 634
Publisher Springer Netherlands
Place of publication Dordrecht, Netherlands
Publication date 2014-12
ISSN 1879-5447
Keyword(s) Automatic stimulation
Closed loop DBS
Deep brain stimulation
Open loop DBS
Science & Technology
Engineering, Biomedical
Summary Deep brain stimulation is an effective and safe medical treatment for a variety of neurological and psychiatric disorders including Parkinson's disease, essential tremor, dystonia, and treatment resistant obsessive compulsive disorder. A closed loop deep brain stimulation (CLDBS) system automatically adjusts stimulation parameters by the brain response in real time. The CLDBS continues to evolve due to the advancement in the brain stimulation technologies. This paper provides a study on the existing systems developed for CLDBS. It highlights the issues associated with CLDBS systems including feedback signal recording and processing, stimulation parameters setting, control algorithm, wireless telemetry, size, and power consumption. The benefits and limitations of the existing CLDBS systems are also presented. Whilst robust clinical proof of the benefits of the technology remains to be achieved, it has the potential to offer several advantages over open loop DBS. The CLDBS can improve efficiency and efficacy of therapy, eliminate lengthy start-up period for programming and adjustment, provide a personalized treatment, and make parameters setting automatic and adaptive.
Language eng
DOI 10.1007/s13246-014-0297-2
Field of Research 090304 Medical Devices
Socio Economic Objective 861502 Medical Instruments
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2014, Springer
Persistent URL

Connect to link resolver
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 27 times in TR Web of Science
Scopus Citation Count Cited 27 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 338 Abstract Views, 2 File Downloads  -  Detailed Statistics
Created: Wed, 11 Mar 2015, 13:58:30 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact