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Australian Enterococcal Sepsis Outcome Programme, 2011

Coombs,GW, Pearson,JC, Le,T, Daly,DA, Robinson,JO, Gottlieb,T, Howden,BP, Johnson,PD, Bennett,CM, Stinear,TP and Turnidge,JD 2014, Australian Enterococcal Sepsis Outcome Programme, 2011, Communicable Diseases Intelligence Quarterly Report, vol. 38, no. 3, pp. E247-E252.

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Title Australian Enterococcal Sepsis Outcome Programme, 2011
Author(s) Coombs,GW
Bennett,CMORCID iD for Bennett,CM
Journal name Communicable Diseases Intelligence Quarterly Report
Volume number 38
Issue number 3
Start page E247
End page E252
Total pages 6
Publisher Australian Government Department of Health and Ageing, Office of Health Protection, Surveillance Branch
Place of publication Canberra, ACT
Publication date 2014-09
ISSN 1447-4514
Keyword(s) Australian Group on Antimicrobial Resistance
Summary From 1 January to 31 December 2011, 29 institutions around Australia participated in the Australian Enterococcal Sepsis Outcome Programme (AESOP). The aim of AESOP 2011 was to determine the proportion of enterococcal bacteraemia isolates in Australia that are antimicrobial resistant, with particular emphasis on susceptibility to ampicillin and the glycopeptides, and to characterise the molecular epidemiology of the Enterococcus faecalis and E. faecium isolates. Of the 1,079 unique episodes of bacteraemia investigated, 95.8% were caused by either E. faecalis (61.0%) or E. faecium (34.8%). Ampicillin resistance was detected in 90.4% of E. faecium but not detected in E. faecalis. Using Clinical and Laboratory Standards Institute breakpoints (CLSI), vancomycin non-susceptibility was reported in 0.6% and 31.4% of E. faecalis and E. faecium respectively and was predominately due to the acquisition of the vanB operon. Approximately 1 in 6 vanB E. faecium isolates however, had an minimum inhibitory concentration at or below the CLSI vancomycin susceptible breakpoint of ≤ 4 mg/L. Overall, 37% of E. faecium harboured vanA or vanB genes. Although molecular typing identified 126 E. faecalis pulsed-field gel electrophoresis (PFGE) pulsotypes, more than 50% belonged to 2 pulsotypes that were isolated across Australia. E. faecium consisted of 73 PFGE pulsotypes from which 43 multilocus sequence types were identified. Almost 90% of the E. faecium were identified as clonal complex 17 clones, of which approximately half were characterised as sequence type 203, which was isolated Australia-wide. In conclusion, the AESOP 2011 has shown that although polyclonal, enterococcal bacteraemias in Australia are frequently caused by ampicillin-resistant vanB E. faecium.
Language eng
Field of Research 111708 Health and Community Services
Socio Economic Objective 920204 Evaluation of Health Outcomes
HERDC Research category C3 Non-refereed articles in a professional journal
ERA Research output type C Journal article
Copyright notice ©2014, Department of Health
Free to Read? Yes
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