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Patterns of care in adult medulloblastoma: results of an international online survey

Cosman,R, Brown,CSB, DeBraganca,KC and Khasraw,M 2014, Patterns of care in adult medulloblastoma: results of an international online survey, Journal of neuro-oncology, vol. 120, no. 1, pp. 125-129, doi: 10.1007/s11060-014-1525-z.

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Title Patterns of care in adult medulloblastoma: results of an international online survey
Author(s) Cosman,R
Brown,CSB
DeBraganca,KC
Khasraw,M
Journal name Journal of neuro-oncology
Volume number 120
Issue number 1
Start page 125
End page 129
Publisher Springer Science & Business Media
Place of publication New York, NY
Publication date 2014-10
ISSN 0167-594X
1573-7373
Keyword(s) Adult medulloblastoma
Chemotherapy
Neurosurgery
Primitive neuroectodermal tumors (PNET)
Radiotherapy
Summary The literature on medulloblastoma in adults is generally limited to case reports and retrospective series, and there is no accepted standard of care. The Cooperative Trials Group for Neuro-Oncology (COGNO) sought to determine the range and consistency of clinicians’ approaches to management as a basis for future trials. We aimed to identify current treatment strategies for adult medulloblastoma through an online survey launched at the 2012 Society of Neuro-Oncology meeting and by email invitation. Clinicians who had treated at least one adult patient with medulloblastoma, primitive neuroectodermal tumor (PNET), or pineoblastoma in the preceding year were asked about their most recent patient and invited to discuss their approach to a typical clinical scenario. Between November 2012 and January 2013, 45 clinicians (11 medical oncologists, 8 radiation oncologists, 5 pediatric oncologists, and 21 others) from Australia (24), United States (3), Europe (4) and other countries (14) completed the survey. Responding clinicians had treated 54 cases in the past 12 months. The most common histological type was medulloblastoma (64 %), then PNET (20 %). Most patients were male (68 %), and had high-risk disease (65 %). Complete surgical resection in 56 and 32 % had molecular testing. Radiotherapy was predominantly cranio-spinal (92 %) and given mostly post-resection (80 %). Combination chemotherapy was more common than single-agent chemotherapy. The choice of chemotherapy varied considerably. There is substantial variation in the treatment of adult medulloblastoma, most pronounced in the choice of chemotherapeutic agents, highlighting the need for further collaborative research to guide evidence-based treatment strategies.
Language eng
DOI 10.1007/s11060-014-1525-z
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 929999 Health not elsewhere classified
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2014, Springer
Persistent URL http://hdl.handle.net/10536/DRO/DU:30070475

Document type: Journal Article
Collection: School of Medicine
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