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Encapsulation of hydrophobic phthalocyanine with poly(N-isopropylacrylamide)/lipid composite microspheres for thermo-responsive release and photodynamic therapy

Liu, Jiaojiao, Li, Jingliang, Zhang, Zexin, Weng, Yuyan, Chen, Gaojian, Yuan, Bing, Yang, Kai and Ma, Yuqiang 2014, Encapsulation of hydrophobic phthalocyanine with poly(N-isopropylacrylamide)/lipid composite microspheres for thermo-responsive release and photodynamic therapy, Materials, vol. 7, no. 5, pp. 3481-3493, doi: 10.3390/ma7053481.

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Title Encapsulation of hydrophobic phthalocyanine with poly(N-isopropylacrylamide)/lipid composite microspheres for thermo-responsive release and photodynamic therapy
Author(s) Liu, Jiaojiao
Li, Jingliang
Zhang, Zexin
Weng, Yuyan
Chen, Gaojian
Yuan, Bing
Yang, Kai
Ma, Yuqiang
Journal name Materials
Volume number 7
Issue number 5
Start page 3481
End page 3493
Total pages 13
Publisher MDPI AG
Place of publication Basel, Switzerland
Publication date 2014-04
ISSN 1996-1944
Keyword(s) Composite microsphere
Controlled release
Phospholipid
Photodynamic therapy
Phthalocyanine
Summary Phthalocyanine (Pc) is a type of promising sensitizer molecules for photodynamic therapy (PDT), but its hydrophobicity substantially prevents its applications. In this study, we efficiently encapsulate Pc into poly(N-isopropylacrylamide) (pNIPAM) microgel particles, without or with lipid decoration (i.e., Pc@pNIPAM or Pc@pNIPAM/lipid), to improve its water solubility and prevent aggregation in aqueous medium. The incorporation of lipid molecules significantly enhances the Pc loading efficiency of pNIPAM. These Pc@pNIPAM and Pc@pNIPAM/lipid composite microspheres show thermo-triggered release of Pc and/or lipid due to the phase transition of pNIPAM. Furthermore, in the in vitro experiments, these composite particles work as drug carriers for the hydrophobic Pc to be internalized into HeLa cells. After internalization, the particles show efficient fluorescent imaging and PDT effect. Our work demonstrates promising candidates in promoting the use of hydrophobic drugs including photosensitizers in tumor therapies.
Language eng
DOI 10.3390/ma7053481
Field of Research 091205 Functional Materials
091202 Composite and Hybrid Materials
090301 Biomaterials
Socio Economic Objective 970109 Expanding Knowledge in Engineering
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2014, The Authors
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30070573

Document type: Journal Article
Collections: Institute for Frontier Materials
Open Access Collection
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.