Collagen type-I leads to in vivo matrix mineralization and secondary stabilization of Mg-Zr-Ca alloy implants

Mushahary,D, Wen,C, Kumar,JM, Lin,J, Harishankar,N, Hodgson,P, Pande,G and Li,Y 2014, Collagen type-I leads to in vivo matrix mineralization and secondary stabilization of Mg-Zr-Ca alloy implants, Colloids and Surfaces B : Biointerfaces, vol. 122, pp. 719-728, doi: 10.1016/j.colsurfb.2014.08.005.

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Title Collagen type-I leads to in vivo matrix mineralization and secondary stabilization of Mg-Zr-Ca alloy implants
Author(s) Mushahary,D
Wen,C
Kumar,JM
Lin,J
Harishankar,N
Hodgson,P
Pande,G
Li,Y
Journal name Colloids and Surfaces B : Biointerfaces
Volume number 122
Start page 719
End page 728
Total pages 10
Publisher Elsevier BV
Place of publication Amsterdam, Netherlands
Publication date 2014-10-01
ISSN 1873-4367
Keyword(s) DXA
Matrix mineralization
Osteoblasts
Osteoinduction
Peri-implant
Science & Technology
Life Sciences & Biomedicine
Physical Sciences
Technology
Biophysics
Chemistry, Physical
Materials Science, Biomaterials
Chemistry
Materials Science
MAGNESIUM ALLOYS
AZ91D ALLOY
GROWTH
TITANIUM
OSSEOINTEGRATION
DIFFERENTIATION
ADHESION
CALCIUM
VITRO
Summary Biodegradable magnesium-zirconia-calcium (Mg-Zr-Ca) alloy implants were coated with Collagen type-I (Coll-I) and assessed for their rate and efficacy of bone mineralization and implant stabilization. The phases, microstructure and mechanical properties of these alloys were analyzed using X-ray diffraction (XRD), optical microscopy and compression test, respectively, and the corrosion behavior was established by their hydrogen production rate in simulated body fluid (SBF). Coll-I extracted from rat tail, and characterized using fourier transform infrared (FT-IR) spectroscopy, was used for dip-coating the Mg-based alloys. The coated alloys were implanted into the femur bones of male New Zealand white rabbits. In vivo bone formation around the implants was quantified by measuring the bone mineral content/density (BMC/BMD) using dual-energy X-ray absorptiometry (DXA). Osseointegration of the implant and new bone mineralization was visualized by histological and immunohistochemical analysis. Upon surface coating with Coll-I, these alloys demonstrated high surface energy showing enhanced performance as an implant material that is suitable for rapid and efficient new bone tissue induction with optimal mineral content and cellular properties. The results demonstrate that Coll-I coated Mg-Zr-Ca alloys have a tendency to form superior trabecular bone structure with better osteoinduction around the implants and higher implant secondary stabilization, through the phenomenon of contact osteogenesis, compared to the control and uncoated ones in shorter periods of implantation. Hence, Coll-I surface coating of Mg-Zr-Ca alloys is a promising method for expediting new bone formation in vivo and enhancing osseointegration in load bearing implant applications.
Language eng
DOI 10.1016/j.colsurfb.2014.08.005
Field of Research 091207 Metals and Alloy Materials
Socio Economic Objective 970109 Expanding Knowledge in Engineering
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2014, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30070576

Document type: Journal Article
Collections: Institute for Frontier Materials
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