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Central pathways causing fatigue in neuro-inflammatory and autoimmune illnesses

Morris, Gerwyn, Berk, Michael, Walder, Ken and Maes, Michael 2015, Central pathways causing fatigue in neuro-inflammatory and autoimmune illnesses, BMC Medicine, vol. 13, no. 28, pp. 1-23, doi: 10.1186/s12916-014-0259-2.

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Title Central pathways causing fatigue in neuro-inflammatory and autoimmune illnesses
Author(s) Morris, Gerwyn
Berk, MichaelORCID iD for Berk, Michael orcid.org/0000-0002-5554-6946
Walder, Ken
Maes, Michael
Journal name BMC Medicine
Volume number 13
Issue number 28
Start page 1
End page 23
Total pages 23
Publisher BioMed Central
Place of publication London, Eng.
Publication date 2015
ISSN 1741-7015
Keyword(s) Science & Technology
Life Sciences & Biomedicine
Medicine, General & Internal
General & Internal Medicine
Immune
Inflammation
Oxidative stress
Toll-like receptor
Fatigue
Mitochondria
Multiple sclerosis
Chronic fatigue syndrome
Parkinson's disease
SYSTEMIC-LUPUS-ERYTHEMATOSUS
PRIMARY SJOGRENS-SYNDROME
MAJOR DEPRESSIVE DISORDER
MAGNETIC-RESONANCE-SPECTROSCOPY
REMITTING MULTIPLE-SCLEROSIS
TUMOR-NECROSIS-FACTOR
TOLL-LIKE RECEPTORS
VOXEL-BASED MORPHOMETRY
CENTRAL-NERVOUS-SYSTEM
RHEUMATOID-ARTHRITIS PATIENTS
Summary The genesis of severe fatigue and disability in people following acute pathogen invasion involves the activation of Toll-like receptors followed by the upregulation of proinflammatory cytokines and the activation of microglia and astrocytes. Many patients suffering from neuroinflammatory and autoimmune diseases, such as multiple sclerosis, Parkinson's disease and systemic lupus erythematosus, also commonly suffer from severe disabling fatigue. Such patients also present with chronic peripheral immune activation and systemic inflammation in the guise of elevated proinflammtory cytokines, oxidative stress and activated Toll-like receptors. This is also true of many patients presenting with severe, apparently idiopathic, fatigue accompanied by profound levels of physical and cognitive disability often afforded the non-specific diagnosis of chronic fatigue syndrome.
Language eng
DOI 10.1186/s12916-014-0259-2
Field of Research 110999 Neurosciences not elsewhere classified
Socio Economic Objective 920111 Nervous System and Disorders
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2015, BioMed Central
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30070601

Document type: Journal Article
Collections: School of Medicine
Open Access Collection
Molecular and Medical Research
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Created: Thu, 12 Mar 2015, 10:02:19 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.