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Acute pain associated with oxaliplatin infusion: case report and literature review

Clay, Timothy D and Ashley, David A 2012, Acute pain associated with oxaliplatin infusion: case report and literature review, Journal of oncology pharmacy practice, vol. 18, no. 4, pp. 421-424, doi: 10.1177/1078155211428999.

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Title Acute pain associated with oxaliplatin infusion: case report and literature review
Author(s) Clay, Timothy D
Ashley, David A
Journal name Journal of oncology pharmacy practice
Volume number 18
Issue number 4
Start page 421
End page 424
Total pages 4
Publisher Sage
Place of publication London, Eng.
Publication date 2012-12-01
ISSN 1078-1552
1477-092X
Keyword(s) oxaliplatin
pain
neurotoxicity
Acute Pain
Antineoplastic Combined Chemotherapy Protocols
Colonic Neoplasms
Fluorouracil
Humans
Leucovorin
Male
Middle Aged
Organoplatinum Compounds
Summary Both acute and chronic neurotoxicities are well-described with the use of oxaliplatin. We describe the case of a 50-year-old man with Dukes C colon carcinoma being treated with an adjuvant FOLFOX4 (5-fluorouracil, leucovorin and oxaliplatin (85 mg/m2 per cycle)) who developed a widespread acute pain 5 min after commencing his twelfth cycle of chemotherapy. The pain was disabling and distressing, and remained for 16 h despite multimodality analgesia. The patient was not rechallenged with oxaliplatin. We believe this presentation represents an acute neurological phenomenon relating to oxaliplatin. Of note, this acute reaction occurred after 11 cycles of treatment, significantly later in the treatment course than other reports of atypical acute reactions.
Language eng
DOI 10.1177/1078155211428999
Field of Research 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
1115 Pharmacology And Pharmaceutical Sciences
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2011, The Authors
Persistent URL http://hdl.handle.net/10536/DRO/DU:30070866

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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