Tuning the mechanical and morphological properties of self-assembled peptide hydrogels via control over the gelation mechanism through regulation of ionic strength and the rate of pH change

Li, Rui, Horgan, Conor C., Long, Benjamin, Rodriguez, Alexandra L., Mather, Lauren, Barrow, Colin J., Nisbet, David R. and Williams, Richard J. 2015, Tuning the mechanical and morphological properties of self-assembled peptide hydrogels via control over the gelation mechanism through regulation of ionic strength and the rate of pH change, RSC advances, vol. 5, no. 1, pp. 301-307, doi: 10.1039/c4ra13266a.

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Title Tuning the mechanical and morphological properties of self-assembled peptide hydrogels via control over the gelation mechanism through regulation of ionic strength and the rate of pH change
Author(s) Li, Rui
Horgan, Conor C.
Long, BenjaminORCID iD for Long, Benjamin orcid.org/0000-0002-3248-8851
Rodriguez, Alexandra L.
Mather, Lauren
Barrow, Colin J.ORCID iD for Barrow, Colin J. orcid.org/0000-0002-2153-7267
Nisbet, David R.
Williams, Richard J.
Journal name RSC advances
Volume number 5
Issue number 1
Start page 301
End page 307
Total pages 7
Publisher Royal Society of Chemistry
Place of publication Cambridge, Eng.
Publication date 2015
ISSN 2046-2069
Keyword(s) Science & Technology
Physical Sciences
Chemistry, Multidisciplinary
Chemistry
PROTEIN SECONDARY STRUCTURE
IN-VIVO
BETA-SHEETS
ARCHITECTURE
NANOTUBES
CELLS
TRANSFORMATION
SCAFFOLDS
CULTURES
Summary Hydrogels formed by the self-assembly of peptides are promising biomaterials. The bioactive and biocompatible molecule Fmoc-FRGDF has been shown to be an efficient hydrogelator via a π-β self-assembly mechanism. Herein, we show that the mechanical properties and morphology of Fmoc-FRGDF hydrogels can be effectively and easily manipulated by tuning both the final ionic strength and the rate of pH change. The increase of ionic strength, and consequent increase in rate of gelation and stiffness, does not interfere with the underlying π-β assembly of this Fmoc-protected peptide. However, by tuning the changing rate of the system's pH through the use of glucono-δ-lactone to form a hydrogel, as opposed to the previously reported HCl methodology, the morphology (nano- and microscale) of the scaffold can be manipulated.
Language eng
DOI 10.1039/c4ra13266a
Field of Research 030306 Synthesis of Materials
Socio Economic Objective 970103 Expanding Knowledge in the Chemical Sciences
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2015, Royal Society of Chemistry
Persistent URL http://hdl.handle.net/10536/DRO/DU:30070979

Document type: Journal Article
Collection: School of Life and Environmental Sciences
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