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A computational search for lipases that can preferentially hydrolyze long-chain omega-3 fatty acids from fish oil triacylglycerols

Kamal, Md. Zahid, Barrow, Colin J. and Rao, Nalam Madhusudhana 2015, A computational search for lipases that can preferentially hydrolyze long-chain omega-3 fatty acids from fish oil triacylglycerols, Food Chemistry, vol. 173, pp. 1030-1036.

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Title A computational search for lipases that can preferentially hydrolyze long-chain omega-3 fatty acids from fish oil triacylglycerols
Author(s) Kamal, Md. Zahid
Barrow, Colin J.ORCID iD for Barrow, Colin J. orcid.org/0000-0002-2153-7267
Rao, Nalam Madhusudhana
Journal name Food Chemistry
Volume number 173
Start page 1030
End page 1036
Total pages 7
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2015-04-15
ISSN 0308-8146
Keyword(s) Covalent docking
DHA
EPA
Lipase
Omega-3 fatty acids
Science & Technology
Physical Sciences
Life Sciences & Biomedicine
Chemistry, Applied
Food Science & Technology
Nutrition & Dietetics
Chemistry
POLYUNSATURATED FATTY-ACIDS
CARDIOVASCULAR-DISEASE
OPTIMIZATION
Summary Consumption of long-chain omega-3 fatty acids is known to decrease the risk of major cardiovascular events. Lipases, a class of triacylglycerol hydrolases, have been extensively tested to concentrate omega-3 fatty acids from fish oils, under mild enzymatic conditions. However, no lipases with preference for omega-3 fatty acids selectivity have yet been discovered or developed. In this study we performed an exhaustive computational study of substrate-lipase interactions by docking, both covalent and non-covalent, for 38 lipases with a large number of structured triacylglycerols containing omega-3 fatty acids. We identified some lipases that have potential to preferentially hydrolyze omega-3 fatty acids from structured triacylglycerols. However omega-3 fatty acid preferences were found to be modest. Our study provides an explanation for absence of reports of lipases with omega-3 fatty acid hydrolyzing ability and suggests methods for developing these selective lipases.
Language eng
Field of Research 060107
Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2015, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30070982

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Created: Thu, 03 Dec 2015, 08:58:45 EST

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