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Bone structure and density via HR-pQCT in 60d bed-rest, 2-years recovery with and without countermeasures

Belavý, D.L., Beller, G., Ritter, Z. and Felsenberg, D. 2011, Bone structure and density via HR-pQCT in 60d bed-rest, 2-years recovery with and without countermeasures, Journal of musculoskeletal and neuronal interactions, vol. 11, no. 3, pp. 215-226.

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Title Bone structure and density via HR-pQCT in 60d bed-rest, 2-years recovery with and without countermeasures
Author(s) Belavý, D.L.ORCID iD for Belavý, D.L. orcid.org/0000-0002-9307-832X
Beller, G.
Ritter, Z.
Felsenberg, D.
Journal name Journal of musculoskeletal and neuronal interactions
Volume number 11
Issue number 3
Start page 215
End page 226
Total pages 12
Publisher International Society of Musculoskeletal and Neuronal Interactions
Place of publication Kifissia, Greece
Publication date 2011-09
ISSN 1108-7161
Keyword(s) Science & Technology
Life Sciences & Biomedicine
Neurosciences
Physiology
Neurosciences & Neurology
micro-CT
3D-pQCT
Spaceflight
Immobilization
Training
TRABECULAR BONE
MECHANICAL-PROPERTIES
POSTMENOPAUSAL WOMEN
MUSCLE ATROPHY
ALENDRONATE
OSTEOPOROSIS
STRENGTH
EXERCISE
Summary We examined the effects of bed-rest, recovery and exercise countermeasures on bone density and structure at the distal tibia and radius as measured via high-resolution peripheral computed tomography. 24 subjects underwent 60-days of head-down tilt bed-rest and performed either resistive vibration exercise (RVE; n = 7), resistive exercise only (RE; n = 8) or no exercise (n = 9; 2nd Berlin BedRest Study; BBR2-2). Measurements were performed regularly during and up to 2-years after 60d bed-rest. At the distal tibia marked reductions in cortical area, cortical thickness and bone density but increases in periosteal perimeter and trabecular area were seen (p all<0.001). Recovery of most parameters occurred within 180d after bed-rest. At the distal radius, persistent increases in cortical area, cortical thickness, cortical density and total density and decreases in trabecular area were seen (p all ≤ 0.005). A significant effect of RVE (p = 0.003), but not RE, was seen on cortical area at the distal tibia, with few effects of the countermeasures observed on the remaining parameters. The current study represents the first implementation of high-resolution peripheral computed tomography in bed-rest in male subjects and helps to understand the patterns of bone remodeling due to bed-rest and recovery.
Language eng
Field of Research 110699 Human Movement and Sports Science not elsewhere classified
Socio Economic Objective 920299 Health and Support Services not elsewhere classified
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2011, International Society of Musculoskeletal and Neuronal Interactions
Persistent URL http://hdl.handle.net/10536/DRO/DU:30071015

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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.