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Changes in intervertebral disc morphology persist 5 mo after 21-day bed rest

Belavý, Daniel L., Bansmann, P. Martin, Böhme, Gisela, Frings-Meuthen, Petra, Heer, Martina, Rittweger, Jorn, Zange, Jochen and Felsenberg, Dieter 2011, Changes in intervertebral disc morphology persist 5 mo after 21-day bed rest, Journal of applied physiology, vol. 111, no. 5, pp. 1304-1314, doi: 10.1152/japplphysiol.00695.2011.

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Title Changes in intervertebral disc morphology persist 5 mo after 21-day bed rest
Author(s) Belavý, Daniel L.ORCID iD for Belavý, Daniel L. orcid.org/0000-0002-9307-832X
Bansmann, P. Martin
Böhme, Gisela
Frings-Meuthen, Petra
Heer, Martina
Rittweger, Jorn
Zange, Jochen
Felsenberg, Dieter
Journal name Journal of applied physiology
Volume number 111
Issue number 5
Start page 1304
End page 1314
Total pages 11
Publisher American Physiological Society
Place of publication Bethesada, Md.
Publication date 2011-11
ISSN 1522-1601
Keyword(s) Science & Technology
Life Sciences & Biomedicine
Physiology
Sport Sciences
microgravity
spaceflight
atrophy
CROSS-SECTIONAL AREA
WHOLE-BODY VIBRATION
LUMBAR SPINE
EXERCISE COUNTERMEASURES
STABILIZING SYSTEM
ASPARTIC-ACID
KNEE-EXTENSOR
HEIGHT AFFECT
FOLLOW-UP
BONE LOSS
Summary As part of the nutrition-countermeasures (NUC) study in Cologne, Germany in 2010, seven healthy male subjects underwent 21 days of head-down tilt bed rest and returned 153 days later to undergo a second bout of 21-day bed rest. As part of this model, we aimed to examine the recovery of the lumbar intervertebral discs and muscle cross-sectional area (CSA) after bed rest using magnetic resonance imaging and conduct a pilot study on the effects of bed rest in lumbar muscle activation, as measured by signal intensity changes in T(2)-weighted images after a standardized isometric spinal extension loading task. The changes in intervertebral disc volume, anterior and posterior disc height, and intervertebral length seen after bed rest did not return to prebed-rest values 153 days later. While recovery of muscle CSA occurred after bed rest, increases (P ≤ 0.016) in multifidus, psoas, and quadratus lumborum muscle CSA were seen 153 days after bed rest. A trend was seen for greater activation of the erector spinae and multifidus muscles in the standardized loading task after bed rest. Greater reductions of multifidus and psoas CSA muscle and greater increases in multifidus signal intensity with loading were associated with incidence of low back pain in the first 28 days after bed rest (P ≤ 0.044). The current study contributes to our understanding of the recovery of the lumbar spine after 21-day bed rest, and the main finding was that a decrease in spinal extensor muscle CSA recovers within 5 mo after bed rest but that changes in the intervertebral discs persist.
Language eng
DOI 10.1152/japplphysiol.00695.2011
Field of Research 110699 Human Movement and Sports Science not elsewhere classified
Socio Economic Objective 920299 Health and Support Services not elsewhere classified
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2011, American Physiological Society
Persistent URL http://hdl.handle.net/10536/DRO/DU:30071016

Document type: Journal Article
Collection: School of Exercise and Nutrition Sciences
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