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Differential atrophy of the lower-limb musculature during prolonged bed-rest

Belavý, Daniel L., Miokovic, Tanja, Armbrecht, Gabriele, Richardson, Carolyn A., Rittweger, Jorn and Felsenberg, Dieter 2009, Differential atrophy of the lower-limb musculature during prolonged bed-rest, European journal of applied physiology, vol. 107, no. 4, pp. 489-499, doi: 10.1007/s00421-009-1136-0.

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Title Differential atrophy of the lower-limb musculature during prolonged bed-rest
Author(s) Belavý, Daniel L.ORCID iD for Belavý, Daniel L. orcid.org/0000-0002-9307-832X
Miokovic, Tanja
Armbrecht, Gabriele
Richardson, Carolyn A.
Rittweger, Jorn
Felsenberg, Dieter
Journal name European journal of applied physiology
Volume number 107
Issue number 4
Start page 489
End page 499
Total pages 11
Publisher Springer
Place of publication Berlin, Germany
Publication date 2009-11
ISSN 1439-6327
Keyword(s) Science & Technology
Life Sciences & Biomedicine
Physiology
Sport Sciences
Berlin Bed Rest Study
Magnetic resonance imaging
Microgravity
Muscle atrophy
HEAD-DOWN-TILT
RESISTANCE EXERCISE
SKELETAL-MUSCLE
KNEE-EXTENSOR
TIBIALIS POSTERIOR
THIGH MUSCLES
BONE LOSS
HIP
COUNTERMEASURE
ACTIVATION
Summary Patients with medical, orthopaedic and surgical conditions are often assigned to bed-rest and/or immobilised in orthopaedic devices. Although such conditions lead to muscle atrophy, no studies have yet considered differential atrophy of the lower-limb musculature during inactivity to enable the development of rehabilitative exercise programmes. Bed-rest is a model used to simulate the effects of spaceflight and physical inactivity. Ten male subjects underwent 56-days of bed-rest. Magnetic resonance imaging of the lower-limbs was performed at 2-weekly intervals during bed-rest. Volume of individual muscles of the lower-limb and subsequently, rates of atrophy were calculated. Rates of atrophy differed (F = 7.4, p < 0.0001) between the muscles with the greatest rates of atrophy seen in the medial gastrocnemius, soleus and vastii (p < 0.00000002). The hamstring muscles were also affected (p < 0.00015). Atrophy was less in the ankle dorsiflexors and anteromedial hip muscles (p > 0.081). Differential rates of atrophy were seen in synergistic muscles (e.g. adductor magnus > adductor longus, p = 0.009; medial gastrocnemius > lateral gastrocnemius, p = 0.002; vastii > rectus femoris, p = 0.0002). These results demonstrate that muscle imbalances can occur after extended periods of reduced postural muscle activity, potentially hampering recovery on return to full upright body position. Such deconditioned patients should be prescribed "closed-chain" simulated resistance exercises, which target the lower-limb antigravity extensor muscles which were most affected in bed-rest.
Language eng
DOI 10.1007/s00421-009-1136-0
Field of Research 110699 Human Movement and Sports Science not elsewhere classified
Socio Economic Objective 920299 Health and Support Services not elsewhere classified
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2009, Springer
Persistent URL http://hdl.handle.net/10536/DRO/DU:30071022

Document type: Journal Article
Collection: School of Exercise and Nutrition Sciences
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