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Heterogeneous atrophy occurs within individual lower limb muscles during 60 days of bed rest

Miokovic, Tanja, Armbrecht, Gabriele, Felsenberg, Dieter and Belavý, Daniel L. 2012, Heterogeneous atrophy occurs within individual lower limb muscles during 60 days of bed rest, Journal of applied physiology, vol. 113, no. 10, pp. 1545-1559, doi: 10.1152/japplphysiol.00611.2012.

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Title Heterogeneous atrophy occurs within individual lower limb muscles during 60 days of bed rest
Author(s) Miokovic, Tanja
Armbrecht, Gabriele
Felsenberg, Dieter
Belavý, Daniel L.ORCID iD for Belavý, Daniel L. orcid.org/0000-0002-9307-832X
Journal name Journal of applied physiology
Volume number 113
Issue number 10
Start page 1545
End page 1559
Total pages 15
Publisher American Physiological Society
Place of publication Bethesada, Md.
Publication date 2012-11-15
ISSN 1522-1601
Keyword(s) Science & Technology
Life Sciences & Biomedicine
Physiology
Sport Sciences
musculature
immobilization
spaceflight
HUMAN SKELETAL-MUSCLE
CROSS-SECTIONAL AREA
RECTUS FEMORIS MUSCLE
HEAD-DOWN-TILT
KNEE-EXTENSOR
NEUROVASCULAR ANATOMY
RESISTANCE EXERCISE
NEURAL ACTIVATION
SARTORIUS MUSCLE
HUMAN QUADRICEPS
Summary To better understand disuse muscle atrophy, via magnetic resonance imaging, we sequentially measured muscle cross-sectional area along the entire length of all individual muscles from the hip to ankle in nine male subjects participating in 60-day head-down tilt bed rest (2nd Berlin BedRest Study; BBR2-2). We hypothesized that individual muscles would not atrophy uniformly along their length such that different regions of an individual muscle would atrophy to different extents. This hypothesis was confirmed for the adductor magnus, vasti, lateral hamstrings, medial hamstrings, rectus femoris, medial gastrocnemius, lateral gastrocnemius, tibialis posterior, flexor hallucis longus, flexor digitorum longus, peroneals, and tibialis anterior muscles (P ≤ 0.004). In contrast, the hypothesis was not confirmed in the soleus, adductor brevis, gracilis, pectineus, and extensor digitorum longus muscles (P ≥ 0.20). The extent of atrophy only weakly correlated (r = -0.30, P < 0.001) with the location of greatest cross-sectional area. The rate of atrophy during bed rest also differed between muscles (P < 0.0001) and between some synergists. Most muscles recovered to their baseline size between 14 and 90 days after bed rest, but flexor hallucis longus, flexor digitorum longus, and lateral gastrocnemius required longer than 90 days before recovery occurred. On the basis of findings of differential atrophy between muscles and evidence in the literature, we interpret our findings of intramuscular atrophy to reflect differential disuse of functionally different muscle regions. The current work represents the first lower-limb wide survey of intramuscular differences in disuse atrophy. We conclude that intramuscular differential atrophy occurs in most, but not all, of the muscles of the lower limb during prolonged bed rest.
Language eng
DOI 10.1152/japplphysiol.00611.2012
Field of Research 110699 Human Movement and Sports Science not elsewhere classified
Socio Economic Objective 920299 Health and Support Services not elsewhere classified
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2012, American Physiological Society
Persistent URL http://hdl.handle.net/10536/DRO/DU:30071033

Document type: Journal Article
Collection: School of Exercise and Nutrition Sciences
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