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Impact of bed rest on conduit artery remodeling: effect of exercise countermeasures

van Duijnhoven, Noortje T.L., Green, Daniel J., Felsenberg, Dieter, Belavý, Daniel L., Hopman, Maria T. E. and Thijssen, Dick 2010, Impact of bed rest on conduit artery remodeling: effect of exercise countermeasures, Hypertension, vol. 56, no. 2, pp. 240-246, doi: 10.1161/HYPERTENSIONAHA.110.152868.

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Title Impact of bed rest on conduit artery remodeling: effect of exercise countermeasures
Author(s) van Duijnhoven, Noortje T.L.
Green, Daniel J.
Felsenberg, Dieter
Belavý, Daniel L.ORCID iD for Belavý, Daniel L. orcid.org/0000-0002-9307-832X
Hopman, Maria T. E.
Thijssen, Dick
Journal name Hypertension
Volume number 56
Issue number 2
Start page 240
End page 246
Total pages 7
Publisher American Heart Association
Place of publication Dallas, Tex.
Publication date 2010
ISSN 1524-4563
Keyword(s) Science & Technology
Life Sciences & Biomedicine
Peripheral Vascular Disease
Cardiovascular System & Cardiology
microgravity
arterial wall
cardiovascular risk
inactivity
exercise training
INTIMA-MEDIA THICKNESS
SPINAL-CORD-INJURY
CAROTID-ARTERY
VASCULAR ADAPTATIONS
MYOCARDIAL-INFARCTION
BLOOD-FLOW
CARDIOVASCULAR EVENTS
TIME-COURSE
RISK-FACTOR
PROGRESSION
Summary Physical inactivity is a potent stimulus for vascular remodeling, leading to a marked decrease in conduit artery diameter. However, little is known about the impact of physical inactivity on artery wall thickness or wall:lumen ratio or the potential of exercise countermeasures to modify artery wall thickness. The purpose of the study was to examine the impact of 60 days of bed rest, with or without exercise countermeasures, on carotid and superficial femoral artery wall thickness. Eighteen men were assigned to bed rest (second Berlin Bed Rest Study) and randomly allocated to control, resistive exercise, or resistive vibration exercise. Both exercise countermeasures were applied 3 times per week while the subjects were in the supine position on the bed. Sonography was used to examine baseline diameter and wall thickness of the carotid and femoral arteries. Bed rest decreased diameter of the superficial femoral artery (P=0.001) but not the carotid artery (P=0.29). Bed rest induced a significant increase in carotid and superficial femoral artery wall thickness (P=0.007 and 0.03) and wall:lumen ratio (P=0.009 and 0.001). Exercise prevented the increase in wall thickness of the carotid artery. In addition, exercise partly prevented the increased wall:lumen ratio in the superficial femoral artery. In conclusion, 8 weeks of bed rest resulted in approximately 20% increase in conduit artery wall thickness. Exercise countermeasures completely (carotid artery) or partly (superficial femoral artery) abolished the increase in wall thickness. These findings suggest that conduit artery wall thickness, a vascular characteristic associated previously with atherosclerosis, can rapidly adapt to physical inactivity and exercise in humans.
Language eng
DOI 10.1161/HYPERTENSIONAHA.110.152868
Field of Research 110699 Human Movement and Sports Science not elsewhere classified
Socio Economic Objective 920299 Health and Support Services not elsewhere classified
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2010, American Heart Association
Persistent URL http://hdl.handle.net/10536/DRO/DU:30071037

Document type: Journal Article
Collection: School of Exercise and Nutrition Sciences
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