Incomplete recovery of lumbar intervertebral discs 2 years after 60-day bed rest

Belavý, Daniel L., Armbrecht, Gabriele and Felsenberg, Dieter 2012, Incomplete recovery of lumbar intervertebral discs 2 years after 60-day bed rest, Spine, vol. 37, no. 14, pp. 1245-1251, doi: 10.1097/BRS.0b013e3182354d84.

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Title Incomplete recovery of lumbar intervertebral discs 2 years after 60-day bed rest
Author(s) Belavý, Daniel L.ORCID iD for Belavý, Daniel L. orcid.org/0000-0002-9307-832X
Armbrecht, Gabriele
Felsenberg, Dieter
Journal name Spine
Volume number 37
Issue number 14
Start page 1245
End page 1251
Total pages 7
Publisher Lippincott, Williams & Wilkins
Place of publication Philadelphia, Pa.
Publication date 2012-06-15
ISSN 1528-1159
Keyword(s) Science & Technology
Life Sciences & Biomedicine
Clinical Neurology
Orthopedics
Neurosciences & Neurology
inactivity
low-back pain
space flight
remodeling
CROSS-SECTIONAL AREA
WHOLE-BODY VIBRATION
IN-VIVO
EXERCISE COUNTERMEASURES
NUCLEUS PULPOSUS
ASPARTIC-ACID
HEIGHT AFFECT
FLUID CONTENT
VOLUME
MRI
Summary STUDY DESIGN: Prospective longitudinal study. OBJECTIVE: To evaluate the recovery of the lumbar intervertebral discs after bed rest. SUMMARY OF BACKGROUND DATA: Prolonged bed rest is a useful model to understand the modeling and remodeling of tissues due to disuse and reloading, yet this process in the lumbar intervertebral discs has not been examined in detail. METHODS: A total of 24 male subjects completed 60 days of head-down tilt bed rest as part of the 2nd Berlin BedRest Study and returned for magnetic resonance scanning 180 days (n = 22) and 2 years (n = 21) after bed rest. Lumbar disc volume, anterior and posterior disc height, disc signal intensity, intervertebral length, and lordosis were measured on sagittal plane magnetic resonance images. RESULTS.: Compared with prior to bed rest, increases in disc volume, disc height, and intervertebral length persisted 180 days (P ≤ 0.0004) and 720 days (P ≤ 0.024) after bed rest. Disc signal intensity remained increased 180 days (P = 0.034) after bed rest but was then decreased (P = 0.018) compared with baseline at the next measurement date. CONCLUSION: The recovery of the lumbar intervertebral discs after 60-day bed rest is a prolonged process and incomplete within 2 years.
Language eng
DOI 10.1097/BRS.0b013e3182354d84
Field of Research 110699 Human Movement and Sports Science not elsewhere classified
Socio Economic Objective 920299 Health and Support Services not elsewhere classified
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2012, Lippincott Williams & Wilkins
Persistent URL http://hdl.handle.net/10536/DRO/DU:30071038

Document type: Journal Article
Collection: School of Exercise and Nutrition Sciences
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