Muscle atrophy, pain, and damage in bed rest reduced by resistive (vibration) exercise

Miokovic,T, Armbrecht,G, Gast,U, Rawer,R, Roth,HJ, Runge,M, Felsenberg,D and Belavý,DL 2014, Muscle atrophy, pain, and damage in bed rest reduced by resistive (vibration) exercise, Medicine and science in sports and exercise, vol. 46, no. 8, pp. 1506-1516, doi: 10.1249/MSS.0000000000000279.

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Title Muscle atrophy, pain, and damage in bed rest reduced by resistive (vibration) exercise
Author(s) Miokovic,T
Armbrecht,G
Gast,U
Rawer,R
Roth,HJ
Runge,M
Felsenberg,D
Belavý,DLORCID iD for Belavý,DL orcid.org/0000-0002-9307-832X
Journal name Medicine and science in sports and exercise
Volume number 46
Issue number 8
Start page 1506
End page 1516
Publisher Lippincott Williams and Wilkins
Place of publication Philadelphia, PA
Publication date 2014-08
ISSN 1530-0315
Keyword(s) Bed Rest
Biological Markers
Creatine Kinase, MM Form
Humans
Leg
Male
Muscular Atrophy
Myalgia
Pain Measurement
Questionnaires
Resistance Training
Vibration
Cross-sectional area
Hypertrophy
Immobilization
Space flight
Training
Science & Technology
Life Sciences & Biomedicine
Sport Sciences
WHOLE-BODY VIBRATION
LOWER-LIMB MUSCLES
COUNTERMEASURE
STRENGTH
RECOVERY
DECREASE
WALKING
INJURY
SPORT
Summary The purpose of this study was to investigate the effectiveness of a short-duration (5-6 min, 3 d·wk) resistive exercise program with (RVE) or without (RE) whole-body vibration in reducing muscle atrophy in the lower limb during prolonged inactivity when compared with that in an inactive control group. METHODS: As part of the second Berlin BedRest Study, 24 male subjects underwent 60 d of head-down tilt bed rest. Using magnetic resonance imaging, muscle volumes of the individual muscles of the lower limb were calculated before and at various intervals during and after bed rest. Pain levels and markers of muscle damage were also evaluated during and after bed rest. Adjustment of P values to guard against false positives was performed via the false discovery rate method. RESULTS: On the "intent-to-treat" analysis, RE reduced atrophy of the medial and lateral gastrocnemius, soleus, vasti, tibialis posterior, flexor hallucis longus, and flexor digitorum longus (P ≤ 0.045 vs control group) and RVE reduced atrophy of the medial and lateral gastrocnemius and tibialis posterior (P ≤ 0.044). Pain intensity reports after bed rest were lower in RE at the foot (P ≤ 0.033) and whole lower limb (P = 0.01) and in RVE at the thigh (P ≤ 0.041), lower leg (P ≤ 0.01), and whole lower limb (P ≤ 0.036). Increases in sarcomere-specific creatine kinase after bed rest were less in RE (P = 0.020) and RVE (P = 0.020). No differences between RE and RVE were observed. CONCLUSIONS: In conclusion, a short-duration RVE or RE can be effective in reducing the effect of prolonged bed rest on lower extremity muscle volume loss during bed rest and muscle damage and pain after bed rest. Copyright © 2014 by the American College of Sports Medicine.
Language eng
DOI 10.1249/MSS.0000000000000279
Field of Research 110602 Exercise Physiology
Socio Economic Objective 920116 Skeletal System and Disorders (incl. Arthritis)
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2014, Lippincott Williams & Wilkins
Persistent URL http://hdl.handle.net/10536/DRO/DU:30071046

Document type: Journal Article
Collection: School of Exercise and Nutrition Sciences
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